Sankyo Company, Limited

Kimio Iino

Yukio Sugimura

Toshihiko Hashimoto

Tomoyuki Shibata

Teruo Tanaka

Shinichi Sugawara

Tomowo Kobayashi

Tetsuo Miyadera

Yoshio Tsujita

Shigeki Muramatsu

Takeshi Kagasaki

Yukiko Kameyama

Yoko Shimada

Masayuki Iwata

Radicicol derivatives in which one or both hydroxy groups are acylated have valuable anti-tumor activity or may be used as chemical intermediates.

Radicicol derivatives, their preparation and their anti-tumor activity

Compounds of formula (I): ##STR1## in which: A and B are separately monoamines or together diamines; and Z is a group of formula (II) or (III): ##STR2## (in which R.sup.1, R.sup.2 and R.sup.7 are various organic groups, n is 0, 1 or 2 and X is a direct carbon-carbon bond or lower alkylene) show valuable anti-tumor activity and may be prepared by reacting an amine-platinum complex with a compound providing the group represented by Z.

Anti-tumor platinum complexes, their preparation and their therapeutic

A compound of the formula ##STR1## in which: R.sup.1 and R.sup.2 are independently selected from the group consisting of hydrogen atoms and groups of formula R.sup.3 --CO--, wherein R.sup.3 represents a group selected from the group consisting of unsubstituted alkyl groups having from 9 to 20 carbon atoms; substituted alkyl groups having from 10 to 20 carbon atoms; unsubstituted alkenyl groups having from 9 to 20 carbon atoms; substituted alkenyl group having from 10 to 20 carbon atoms; unsubstituted alkynyl groups having from 8 to 10 carbon atoms; and substituted alkynyl groups having from 8 to 10 carbon atoms wherein R.sup.1 and R.sup.2 are not both hydrogen atoms or acetyl groups. The compounds have antitumor activity.

Compounds of formula (I): ##STR1## wherein: one or both of R.sup.1 and R.sup.2 are selected from a variety of organic groups;

2-(1-aceti

Compounds of formula (I): ##STR1## (wherein R.sup.1 is carboxy, --CONR.sup.4 R.sup.5, cyano or hydroxymethyl, and R.sup.2 and R.sup.3 are hydrogen, alkyl or substituted alkyl, R.sup.4 and R.sup.5 being hydrogen or a variety of groups) have good antibiotic activity and reduced renal toxicity.

Carbapenem compounds and use

Compounds of formula (I): ##STR1## in which: R.sup.1 represents a hydrogen atom, an alkyl group, an alkoxy group or various substituted alkyl groups;

2-penem-3-carboxylic acid derivatives and use

Compounds of formula (I): ##STR1## (wherein R.sup.1 represents a C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.3 alpha-hydroxyalkyl group;

Penem derivatives, and composition containing them

Compounds of formula (I): ##STR1## [wherein: R.sup.1 represents a hydrogen atom, an alkyl group, an alkoxy group or various substituted alkyl groups;

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Hiromachi, Japan

Kimio Iino