Mect Corporation

Kanto Ishi Pharmaceutical Co., Ltd.

Kimio Furuhata

Masayoshi Ito

Yoshiyasu Shitori

Haruo Ogura

Yoshitaka Nagai

Toshiaki Osawa

Satoshi Toyoshima

Shingo Sato

Shoji Yoshimura

The present invention relates to a sodium salt of sialosyl cholesterol. The present compound has an excellent high water solubility, and therefore the compound is very useful as a medicine to be used for treating various diseases derived from lesions of peripheral or central nerves.

Sialosyl cholesterol and neuropathy remedy comprising the same

Sialosyl cholesterol, process for producing the same, and neuropathy

A new process for preparing halides of N-acetylneuraminic acids useful as an intermediate in preparing new N-acetylneuraminic acid derivatives having an excellent immunological activity is provided, which process comprises simultaneously acetylating and halogenating an esterified N-acetylneuraminic acid with the aid of an acetyl halide, and according to the process, the halides may be obtained in high yield of about 90%.

Process for preparing N-acetylneuraminic acid derivatives

This invention provides a novel compound having the following formula: ##STR1## This compound is a useful intermediate for the preparation of N-glycolylneuraminic acid: ##STR2##

N-glycolylneuraminic acid derivative

A novel N-acetylneuraminic acid derivative, represented by the general formula: ##STR1## wherein the R.sup.1 groups are, independently, hydrogen or acetyl; R.sup.2 is a nucleoside residue; and R.sup.3 is carboxyl or methoxycarbonyl. The N-acetylneuraminic acid derivative is useful in inhibiting metastasis of cancer cells. Also provided is a process for the preparation of the derivatives.

Sialic acid derivative and process for preparing the same

Nucleoside or glucose derivatives of N-acetylneuraminic acids are provided, which have immunological activity, are clinically useful, as an immuno suppressive, in particular to treat autoimmune disease such as collagenosis disease without causing any serious side-effects and may be prepared by subjecting a halide of N-acetylneuraminate derivative together with a nucleoside or a glucose to Koenigs-Knorr reaction.

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Tokyo, Japan

Kimio Furuhata