Toyama Chemical Co., Ltd.

Kimiko Morimoto

Yukihiko Aikawa

Keiichi Tanaka

Shunichi Shiozawa

Mari Yamamoto

A method for treating the relapsing-remitting or secondary progressive multiple sclerosis at the time of relapse, by administering a benzopyran derivative of the following formula or a salt thereof, where Rrepresents an optionally substituted Calkyl group, one of Rand Rrepresents a hydrogen atom, and the other of Rand Rrepresents a hydrogen atom, an optionally substituted amino group, an optionally substituted acylamino group, an optionally substituted carbamoyl group or an optionally substituted aryl group.

Therapeutic agent for disease based on inhibitory effect of macrophage migration inhibitory factor

Pharmaceutical agents characterized by containing benzophenone derivatives represented by the general formula: wherein the each substituent is as defined in the specification, or salts thereof have suppressive effect on RANKL production, suppressive effect on OPG reduction and inhibitory effects on differentiation/activation of osteoclasts, and are extremely useful for treating, for example therapy and/or prevention, of various diseases in which differentiation/activation of osteoclast are involved, such as osteoporosis.

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Toyama, Japan

Kimiko Morimoto