Takeda Pharmaceutical Company Limited

Takeda Chemical Industries, Inc.

Kimiko Kanehashi

Takuya Watanabe

Chieko Kitada

Tetsuya Ohtaki

Yasushi Shintani

Yasuko Terao

Masaaki Mori

The present invention provides a medicament for preventing/treating cancer, comprising a tacrine compound, or a compound promoting the binding between the tacrine compound and a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1.

Screening method

The present invention relates to rat cerebellum-derived and human brain-derived G protein coupled receptor proteins or salts thereof, their partial peptides, amides, esters or salts thereof, ligands to the same, a method/kit for screening compounds that alter the binding property between the ligands and the G protein coupled receptor proteins, compounds obtained by the screening or salts thereof, and antibodies to the G protein coupled receptor proteins.

Screening assay using G-protein coupled receptor protein OT7T175

G Protein-coupled receptor proteins originating in the vicinity of rat brain stem and human brain or salts thereof, or peptide fragments thereof or amides, esters or salts of the same; ligands thereto; a method/kit for screening compounds capable of altering the binding properties of the ligands to the G protein-coupled receptor proteins; the compounds or salts thereof obtained by the above screening; antibodies against the G protein-coupled receptor proteins, etc.

Peptides that activate the G-protein coupled receptor protein, 0T7T175

Growing community of inventors

Ibaraki, Japan

Kimiko Kanehashi