Shiseido Company, Limited

Kimihiro Ogino

Kiyoshi Sato

Takako Shibata

Tomoko Saito

Naoto Hanyu

Naota Hanyu

The present invention provides a compound having an excellent inhibitory action on melanin production and being useful as a whitening agent, and a skin external preparation containing the compound. The whitening agent of the present invention comprises, as an active ingredient, a compound represented by formula (1) or a pharmacologically acceptable salt thereof: wherein X, X, and Xare each CRor N; R, R, and Rare each H, Calkyl, Calkoxy, SH, OH, or NRR, wherein Rand Rare each H, Calkyl, or hydroxy-Calkyl, or NRRforms a saturated or unsaturated 5- or 6-membered hetero ring; and B is a substituted or unsubstituted pyrazole, imidazole, pyridine, or piperidine; with the proviso that at least one of R, R, R, and Ris a group other than Calkyl in the case where X&#x2550;X&#x2550;Y&#x2550;N and X&#x2550;CR.

Whitening agent and skin external preparation

The present invention provides a compound having an excellent inhibitory action on melanin production and being useful as a whitening agent, and a skin external preparation containing the compound. The whitening agent of the present invention comprises, as an active ingredient, a compound represented by formula (1) or a pharmacologically acceptable salt thereof: wherein, R, R, R, and Rare each independently Calkyl; and Rand Rare each independently a hydrogen atom or Calkyl.

Method for inhibiting melanin production and whitening skin with pyrimidlypyrazole compounds or pharmaceutically acceptable salts thereof

Method for inhibiting melanin production and whitening skin with pyrimidylpyrazole compounds or pharmaceutically acceptable salts thereof

The present invention provides a compound having an excellent inhibitory action on melanin production and being useful as a whitening agent, and a skin external preparation containing the compound. The whitening agent of the present invention comprises, as an active ingredient, a heterocyclic compound represented by formula (1) or a pharmacologically acceptable salt thereof: wherein R, R, and R' are each independently Calkyl; Y is S or O; and p is an integer of 0 to 3, wherein when p is 2 or 3, Rmay be the same or different.

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Yokohama, Japan

Kimihiro Ogino