Koken Company, Limited

Dainippon Sumitomo Pharma Co., Ltd.

Taisho Pharmaceutical Co., Ltd.

National Cancer Center

Japan As Represented by President of National Cancer Center

Sumitomo Dainippon Pharma Co., Ltd.

Kimi Honma

Takahiro Ochiya

Akihiko Sano

Masaaki Terada

Kikuya Kato

Yu Aso

Shunji Nagahara

Yasuji Ueda

Means for transferring efficiently a desired nucleic acid into a cell is provided. The present invention comprises using a complex comprising a collagen or a collagen derivative, and a desired nucleic acid.

Method of promoting nucleic acid transfer

The present invention uses an RPN2 gene expression inhibitor as a cancer cell growth inhibitor, which further includes a drug showing an anti-cancer action if desired, and is administered in combination with atelocollagen if desired. In addition, the present invention is an anti-cancer agent including such cancer cell growth inhibitor.

Method of treating cancer with an RPN2 gene expression inhibitor

The subject of the present invention is to provide a microarray for introducing nucleic acid, the microarray capable of introducing and expressing nucleic acid into cells simply by adding the nucleic acid onto a plate and the like, and then seeding the cells thereon and culturing them without adding a nucleic acid-introducing reagent or additives. The subject is achieved by preparing the microarray including atelocollagen, a gene-introducing agent and nucleic acid on a plate and the like for the introduction of nucleic acid. The nucleic acid can be introduced into a cell by seeding cells into which nucleic acids are introduced on the microarray and culturing them without the need of preparing a mixture of viral vectors, nucleic acids and a nucleic acid-introducing agent after culturing cells or the need of adding a nucleic acid-introducing agent and additives.

Cell transfection array for introduction of nucleic acid

Growing community of inventors

Tokyo, Japan

Kimi Honma