Altor Bioscience Corporation

The Scripps Research Institute

Kimberlyn F Card

Hing C Wong

Jon A Weidanz

Linda A Sherman

Xiaoyun Zhu

Shari A Price-Schiavi

Heather J Belmont

Norman R Klinman

Elizabeth L Thomson

Disclosed are compositions and methods for detecting cells or tissue comprising a peptide antigen presented in the context of an MHC or HLA complex. The invention has a wide range of applications including providing a highly sensitive method for detecting cancer cells.

Soluble TCR molecules and methods of use

The present invention relates to polyspecific binding molecules and particularly single-chain polyspecific binding molecules that include at least one single-chain T-cell receptor (sc-TCR) covalently linked through a peptide linker sequence to at least one single-chain antibody (sc-Ab). Further disclosed are methods and compositions for testing and using the molecules.

Polyspecific binding molecules and uses thereof

The invention provides T-cell receptor (TCR) molecules comprising a V&#x3b1; chain and a V&#x3b2; chain that bind peptides derived from the p53 protein, preferably, the human p53 protein. The TCR molecules include both heterodimeric molecules and single chain molecules which specifically bind a sequence preferably spanning about amino acid positions 264-272 of the p53 protein displayed in the context of an HLA molecule, preferably, HLA-A2.1. Also disclosed are methods for making and using such TCR molecules. The invention has a wide spectrum of useful application including therapeutic uses and use in the detection of cells expressing p53 protein.

P53 binding T cell receptor molecules

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Pembroke Pines, FL, United States of America

Kimberlyn F Card