The Dow Chemical Company

Pfizer Corporation

The United States of America, as Represented by the Secretary, Department of Health and Human Services

Kimberly S Johnson

Peter S Mezes

Ruth A Richard

Jeffrey Schlom

Eduardo Agustin Padlan

Syed V S Kashmiri

Thomas J Johnson

Ivan G Otterness

Liming Shu

James T Downs

Mary J Saltarelli

Sizing device assembly for clothing, fabrics, and garments

Sizing device for clothing, fabrics and garments

Novel composite and humanized anti-TAG-72 monoclonal antibodies, antibody fragments, and derivatives thereof using human subgroup IV kappa light chain framework regions.

Composite antibodies of humanized human subgroup IV light chain capable of binding to TAG-72

This invention provides novel methods for monitoring urine for type II collagen fragment using a combination of a capture antibody and a detection antibody, such that type II collagen is distinguished from other collagen fragments.

Assays for measurement of type II collagen fragments in urine

Humanized anti-tag-72 monoclonal antibodies using human subgroup 4 kappa light chains

This invention provides novel antibodies and engineered versions thereof and methodology for monitoring biological media for protein fragments, especially collagen fragments resulting from collagenase cleavage of type II collagen.

Assays for measurement of protein fragments in biological media

This invention concerns a subset of composite Hum4 V.sub.L, V.sub.H antibodies with high affinities to a high molecular weight, tumor-associated sialylated glycoprotein antigen (TAG-72) of human origin. These antibodies have variable regions with (1) V.sub.L segments derived from the human subgroup IV germline gene, and (2) a V.sub.H segment which is capable of combining with the V.sub.L to form a three dimensional structure having the ability to bind TAG-72. In vivo methods of treatment and diagnostic assay using these composite antibodies is also disclosed.

Composite antibodies of human subgroup IV light chain capable of binding

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Gales Ferry, CT, United States of America

Kimberly S Johnson