Vioptix, Inc.

Medibeacon Inc.

Kimberly Merritt Shultz

Kate LeeAnn Bechtel

Alex Michael Margiott

Jennifer Elizabeth Keating

Edward Gerald Solomon

Jennifer Keating

Joseph A Heanue

Scott Coleridge

George Edward Kechter

Martin Paul Debreczeny

An oximeter probe determines an oxygen saturation for the tissue and determines a quality value for the oxygen saturation and associated measurements of the tissue. The quality value is calculated from reflectance data received at the detectors of the oximeter probe. The oximeter probe then displays a value for the oxygen saturation with the error value to indicate a quality level for the oxygen saturation and associated values used to calculate oxygen saturation.

Measuring oxygen saturation with quality metric reporting

A method of assessment of renal function by monitoring a time-varying fluorescence signal emitted from a fluorescent agent from within a diffuse reflecting medium with time-varying optical properties is provided that includes using a renal monitoring system comprising at least one light source, at least one light detector, at least one optical filter, and at least one controller to provide a measurement data set comprising a plurality of measurement entries, each measurement data entry comprising at least two measurements obtained at one data acquisition time from a patient before and after administration of the fluorescent agent.

Method for non-invasive monitoring of fluorescent tracer agent with diffuse reflecting medium with time-varying optical properties

A probe tip of an oximeter device includes first and second printed circuit boards (PCBs) that are coupled to the ends of optical fibers that transmit light between the PCBs and into patient tissue that is to be measured by the oximeter device. The PCBs are oriented at an angle between zero and ninety degrees so that the fibers have a curved shape between the locations at which the fibers are coupled to the first and second PCBs. The angular orientation of the PCBs and curved shape of the fibers allows the fibers to have a longer length than if the fibers were straight and allows for light transmitted through the fibers to have a uniform distribution across a cross-section of the fibers as the light is emitted from the fibers into patient tissue. The uniform distribution of light transmitted into patient tissue allows for reliable oximetry measurements.

Probe tip assembly and bezel for medical device

Tissue oxygen saturation with quality metric reporting

An oximeter probe that takes into account tissue color (e.g., skin color or melanin content) to improve accuracy when determining oxygen saturation of tissue. Light is transmitted from a light source into tissue having melanin (e.g., eumelanin or pheomelanin). Light reflected from the tissue is received by a detector. A compensation factor is determined to account for absorption due to the melanin. The oximeter uses this compensation factor and determines a melanin-corrected oxygen saturation value.

Determining tissue oxygen saturation with melanin correction

Probe tip for medical device

Determining tissue oxygen saturation with quality reporting

A method of monitoring a time-varying fluorescence signal emitted from a fluorescent agent from within a medium with time-varying optical properties is provided that includes providing a measurement data set that includes a plurality of measurement entries that include at least two measurements obtained from a patient before and after administration of the fluorescent agent. The measurements may include one or more of: a DRsignal detected by an unfiltered light detector during illumination by excitatory-wavelength light from first region adjacent to the diffuse reflecting medium; a Flr signal detected by a filtered light detector during illumination by excitatory-wavelength light; and a DRsignal detected by the unfiltered light detector during illumination by emission-wavelength light. The method further includes identifying a post-agent administration portion of the measurement data set; and transforming each Flr signal to an IF signal representing a detected fluorescence intensity emitted solely by the fluorescent agent.

Method for non-invasive monitoring of fluorescent tracer agent with diffuse reflection corrections

A sensor head is provided. In any of the various aspects of the invention, the sensor head has a housing enclosing at least two light sources configured to deliver light to a patient and comprising a blue LED first light source that delivers light at an excitatory wavelength and a green LED second light source, and at least one light detector configured to detect light at an emission wavelength from the patient. The sensor is useful for non-invasive monitoring of fluorescent tracers agents.

Sensor head for non-invasive monitoring of a fluorescent tracer agent

A method of monitoring a time-varying fluorescence emitted from a fluorescent agent from within a diffuse reflecting medium with time-varying optical properties is disclosed that includes providing at least two measurements obtained from a patient before and after administration of the fluorescent agent that includes an Flrsignal detected adjacent to the medium by a filtered light detector during illumination of the medium by excitatory-wavelength light, and at least one DR signal selected from: a DRDR, and DRsignal. The method further includes identifying a post-equilibration portion of the measurement data set and transforming each Flrsignal within the post-equilibration portion of the measurement data set to an IFsignal representing a detected fluorescence intensity emitted solely by the fluorescent agent from within the medium. The disclosed method includes removing the effects of leak-through of excitation-level light and removing the effects of autofluorescence from the Flrsignal.

Growing community of inventors

Mountain View, CA, United States of America

Kimberly Merritt Shultz