Diagnologix, LLC

Pensievision, Inc.

Kimberly Liu

Guixin Shi

Ying-Ting Wang

David Melnick

Sadik Esener

Elyana Crowder

Joseph Carson

A method for activating and expanding isolated T cells, the method including adding to isolated T cells ligands presenting microbubbles having a flexible lipid shell with an inner bubble wall enclosing a gas and an outer bubble wall conjugated to ligands capable of achieving cell contact dependent juxtacrine signaling on the isolated T cells; and adding to isolated T cells ligands presenting microbubbles having a flexible lipid shell with an inner bubble wall enclosing a gas and an outer bubble wall conjugated to an antigen capable of forming an immunological synapse (IS) with the T cells.

Method for activating and expanding isolated T cells

A system, device, and accompanying software for the remote, three-dimensional, and high-throughput imaging and analysis of human lesions, across a range of wavelengths, lens radii and imaging sensors. This system, device, and software generates and analyses of tumor images at infrared wavelengths through the use of miniaturized, liquid lenses. It has a number of clinical, diagnostic, research, and other imaging applications, including the remote, three-dimensional, and high-throughput imaging and analysis of human cancer tumors.

Method, system, software, and device for remote, miniaturized, and three-dimensional imaging and analysis of human lesions research and clinical applications thereof

A buoyancy enabled separation method for isolation from a sample including a variety of different cells a sparse subset of cells that is differentiated by a plurality of different cell surface markers. Microbubbles conjugated to antibodies are applied sequentially in a container with the previously used microbubbles disrupted prior to applying the next microbubbles conjugated to a different antibody. A system that includes a syringe-like container with a plunger and closeable opening. Further, a method for activating and expanding isolated T cells by applying antigen presenting microbubbbles having a flexible lipid shell mimicking an antigen presenting cell for generating immunological synapses.

Buoyancy enabled separation method and system

Growing community of inventors

San Diego, CA, United States of America

Kimberly Liu