Massachusetts Institute of Technology

The United States of America, as Represented by the Secretary, Department of Health and Human Services

Kimberly Hamad-Schifferli

Lee Gehrke

Irene Bosch

Jose Gomez-Marquez

Sunho Park

Jacqueline Callihan Linnes

Salmaan H Baxamusa

David K Wood

Helena De Puig Guixe

Helena dePuig Guixe

Nevan Clancy Hanumara

Helena De Puig

The present invention provides matched antibody pairs for the specific detection of one or more of the four dengue virus serotypes in a biological sample that may contain one or more of such dengue virus serotypes. Each matched antibody pair is capable of detecting not more than one serotype of dengue virus NS1 protein that may be present in the sample and will not cross react with other serotypes that may be present in the sample. Multiple matched pairs may be used to detect one or more dengue virus serotypes that may be present in a sample. Such matched pair antibodies, facilitate the development of confirmatory in vitro diagnostic tests such as sandwich immunoassays, that detect and distinguish the presence of one or more dengue virus serotypes in a biological sample, preferably a sample derived from human subject. The invention also provides kits comprising the matched antibody pairs of the invention and methods for using the kits for immunoassays for the specific detection of one or more serotypes of dengue virus in a patient population. The present invention also provides monoclonal antibodies specific for the NS1 protein of dengue virus and therapeutic compositions and methods for treating dengue virus infection.

Anti-dengue virus NS1 protein monoclonal antibodies

The disclosure is directed to enabling reversible, on-demand remote control of blood clotting and clot dissolution. In one embodiment, a laser at one wavelength triggers release of a DNA thrombin inhibitor from one nanorod, which acts as an anticoagulant to stop blood clotting. Another wavelength triggers release of a specific antidote, which reverses the effect of the thrombin inhibitor, restoring blood clotting.

Blood clotting control

Exemplary embodiments provide diagnostic devices, systems and methods for determining the presence or absence of one or more markers or characteristics in one or more samples. An exemplary diagnostic device may display a first two-dimensional machine-readable output to indicate the presence or absence of a first characteristic in a sample. Similarly, the exemplary diagnostic device may display a second two-dimensional machine-readable output to indicate the presence or absence of a second characteristic in a sample. An image capture device may be used to automatically detect the two-dimensional machine-readable output appearing in the diagnostic device. A computational device may be used to automatically determine whether the presence or absence of the first characteristic and/or the second characteristic based on the two-dimensional machine-readable output displayed in the diagnostic device.

Systems, devices and methods for multiplexed diagnostics

Provided herein are kits and methods suitable for enhancing in vitro translation of a nuclei acid sequence of interest.

Enhancement of in vitro translation by nanoparticle conjugates

Growing community of inventors

Somerville, MA, United States of America

Kimberly Hamad-Schifferli