Biomimetix Jv, LLC

Duke University

Kimberly C Stone

James D Crapo

Ines Batinic-Haberle

Ru-Rong Ji

David S Warner

Tong Liu

A method of treating pruritus (itching) in a subject in need thereof is carried out by administering the subject an active agent in a treatment effective amount, wherein the active agent is a superoxide dismuate (SOD) mimetic. The SOD mimetic can be a complex of a metal (e.g., manganese) and an organic ligand, with suitable organic ligands including porphyrins, polyamines, salens, nitroxides, and fullerenes. Compositions for carrying out such methods are also described.

Methods of treating pruritus

A method of treating a skin disorder (e.g., an inflammatory or neoplastic skin disorder) in a subject in need thereof is carried out by administering (e.g., topically administering) the subject an active agent in a treatment effective amount. The active agent may be a compound of Formula I: wherein: each R is independently selected substituted or unsubstituted aryl, heteroaryl, cycloalkyl, or heterocycloalkyl; each A is an independently selected hydrogen, an electron-withdrawing group, or electron donating group; M is a metal; and Zis a counterion; or a pharmaceutically acceptable salt thereof. 

Methods of treating skin disorders

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Greenwood Village, CO, United States of America

Kimberly C Stone