Medtronic, Inc.

Ford Global Technolgoies, LLC

Exxonmobil Chemical Patents Inc.

University of Minnesota

Sdgi Holdings, Inc.

Sofradim Production

Warsaw Orthopedic, Inc.

Kimberly A Chaffin

Andrew J Ries

Randy S Roles

Paul B Aamodt

Kurt J Casby

Scott J Robinson

David P Haas

Walter Carl Sunderland

Karl E Hokanson

Thomas M Nutzman

Sonja K Somdahl

Steve M Bruesehoff

Franise D Bartley

Darrel F Untereker

Xiangji Chen

Jason T Papenfuss

William J Farrell

Matthew Jolly

Suping Lyu

Frank Steven Bates

James John Kempf

Zhaoxu Wang

Peter L Thor

Mark Christian Timney

Patrick Brant

Hai H Trieu

Orhan Soykan

Marc Andrew Hillmyer

Markus W Reiterer

Carl A Schu

Michael F Wolf

Lisa M Lim

Darlene Nebinger

Julie A Alkatout

Ashish Varma

Ray Alexander Dickie

Thomas P Grailer

Peter T Schroeder

Adam J Buckalew

Yves Bayon

Angela M Throm Quinlan

Systems and methods for tissue engineered synthetic support structures, such as grafts and patches are provided. The systems and methods can be used to make tissue engineered planar sheathes or meshes that can be fashioned into substantially planar or non-planar 3D tissue/organ structures adaptable to structure and organs within a human or mammalian body. The systems and methods can use bioink deposited on a material having specified properties and matured under specified conditions to create the tissue engineered planar sheathes or meshes having biomechanical and biological properties tailored to a particular tissue.

Tissue engineered synthetic support structure

A modified polyisobutylene-based polymer, method of making, and a medical device that includes such polymer, wherein the modified polyisobutylene-based polymer includes urethane, urea, or urethane-urea groups, hard segments, and soft segments, wherein the soft segments comprise phenoxy-containing polyisobutylene residues, and the hard segments include diisocyanate residues and optionally chain extender residues.

Modified polyisobutylene-based polymers, methods of making, and medical devices

Medical leads, such as medical electrical leads and medical neurological leads, that include a polymeric material that includes a silicone-urethane-containing polymer having improved hydrolytic stability.

Medical leads

A battery having an electrode assembly located in a housing that efficiently utilizes the space available in many implantable medical devices is disclosed. The battery housing provides a cover and a shallow case a preferably planar, major bottom portion, an open top to receive the cover opposing the bottom portion, and a plurality of sides being radiused at intersections with each other and with the bottom to allow for the close abutting of other components located within the implantable device while also providing for efficient location of the battery within an arcuate edge of the device. The cover and the shallow case being substantially hermetically sealed by a laser weld technique and an insulator member disposed within the case to provide a barrier to incident laser radiation so that during welding radiation does not impinge upon radiation sensitive component(s) disposed within the case.

Contoured battery for implantable medical devices and method of manufacture

The invention relates to a method and device for dialysis and or bulk fluid removal by generating a fibrosis chamber within a body cavity and performing dialysis or bulk fluid removal. An implantable medical device is described having a fibrosis chamber and a pump. A dialysis chamber and an optional electrodialysis unit can further be provided. An additional controller uses sensory feedback to regulate the fluid levels by altering the extracellular fluid retention within the fibrosis chamber. This device can be used for the treatment of patients with chronic kidney disease who may also be suffering from cardiorenal syndrome and hypertension.

Method and device to treat kidney disease

Contoured battery for implantable medical devices

A process for producing a dilatation balloon by extruding a multiblock copolymer composition to form an extrudate comprising phase-separated glassy, rubber, and semicrystalline microdomains that are macroscopically ordered in a perpendicular alignment. The balloon formed by the process demonstrates, during inflation, a true stress vs. nominal strain response curve comprising a first zone representative of a low modulus balloon, a second zone representative of a high strength balloon, and a sharp transition from the first zone to the second zone.

Process for producing a hyper-elastic, high strength dilatation balloon made from multi-block copolymers

A method for coating a medical device with a drug is provided. Energy, preferably thermal energy, is applied to a crystalline deposit of a drug on the surface of a medical device to increase the molecular mobility and form a conformable drug coating with a low density of micro-cracks and other mechanical defects that can degrade the coating toughness and effective adhesion to the device surface. In a preferred embodiment, solution evaporation methods are used to deposit a crystalline coating of an anti-inflammatory steroid on a medical electrode. Heat applied at a controlled temperature, for a predetermined amount of time, induces a solid-state phase change of the drug coating providing a smooth, uniform, well-attached, conformable coating to form a layer that will elute from the electrode over time when implanted in a patient's body.

Method for applying a drug coating to a medical device

Orthopedic compositions are provided that include a homogeneous mixture of a biocompatible polymer and a bioactive particulate ceramic wherein the ceramic has an average particle size of not more than 500 nm are provided. The compositions may be used to form bone cement or various spinal implants, including spinal spacers, interbody fusion cages, bone plates and bone screws. Methods for stabilizing a spine, for correcting a bone defect, and for promoting fusion of adjacent vertebrae are also provided.

Bioactive nanocomposites and methods for their use

A battery having an electrode assembly located in a housing that efficiently utilizes the space available in many implantable medical devices is disclosed. The battery housing provides a cover and a shallow case a planar bottom, an open top to receive the cover, and a plurality of sides being radiused at intersections with each other and with the bottom to allow for the close abutting of other components located within the implantable device while also providing for efficient location of the battery within an arcuate edge of the device.

Plastics toughened plastics are metallocene catalyzed polyethylenes (mPE) and isotactic polypropylene (iPP). These plastic toughened plastics are useful in molded articles, most especially automotive interior trim parts. The mPE can be present in such toughened plastics from 5-40 weight percent, the iPP from 60-95 weight percent. The toughened plastics will have an excellent balance of tensile toughness, elongation and modulus at &minus;10&deg; C. Generally the tensile toughness will be 25-250% greater than the tensile toughness of a similarly proportioned blend of Ziegler-Natta catalyst produced polyethylene/iPP.

Plastic toughened plastics

A bonded multi-piece plastic automotive air intake assembly having first and second housing members that include a 3-dimensional mating surface. The first member has a continuous first perimeter edge and the second member has a continuous second perimeter edge. The first perimeter edge has a central tongue portion that extends outwardly from the first edge. The tongue portion has first and second wall surfaces. The second peripheral edge has a groove extending inwardly from the second peripheral edge and mates with the tongue portion. The tongue portion and groove form a U-shaped channel that receives an adhesive therebetween. The adhesive forms a continuous bead that seals the channel between the first and second housing members. A plurality of alignment spacers are positioned between the tongue portion and the groove to align the tongue portion centrally within the groove.

Adhesively bonded plastic automotive air intake assembly

Growing community of inventors

Plymouth, MN, United States of America

Kimberly A Chaffin