Genentech, Inc.

Array Biopharma Inc.

Kim Malesky

Alexandre Joseph Buckmelter

Li Ren

David A Moreno

Ellen Ruth Laird

Bainian Feng

Wendy B Young

Brad Newhouse

Simon Mathieu

Janet Gunzner

Joachim Rudolph

Jonas Grina

Zhaoyang Wen

Steven Mark Wenglowsky

Kateri Ahrendt

Joshua D Hansen

Jeongbeob Seo

Hongqi Tian

Jason De Meese

Paul Lunghofer

Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. 

Pyrazole [3, 4-B] pyridine Raf inhibitors

Compounds of Formula (I) are useful for inhibition of Raf kinases. Methods of using compounds of Formula (I) and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. 

Raf inhibitor compounds and methods of use thereof

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South San Francisco, CA, United States of America

Kim Malesky