Inozyme Pharma, Inc.

Alexion Pharmaceuticals, Inc.

Westfaelische Wilhelms-universitaet Muenster

Kim Lynette Askew

Anthony Quinn

Tayeba Khan

Nelson Hsia

Andre Marozsan

Gregory A Grabowski

Zhiliang Cheng

W Charles O'Neill

Yan Yan

Susan Faas Mcknight

Frank Rutsch

Kiran Patki

Herman Griffin

Robert John Lyng

Ashmita Saigal

Sandra Rojas-Caro

Anumeha Shah

Yvonne Nitschke

Anthony Rossomando

The present invention provides methods for improving cardiovascular function in a human patient (e.g., reducing hypertension), as well as methods of treating a cardiovascular disease, by administering a recombinant human soluble ectonucleotide pyrophosphatase phosphodiesterase (hsNPP1), active fragment or fusion protein thereof.

Methods of improving cardiovascular function and treating cardiovascular disease using a recombinant ectonucleotide pyrophosphatase phosphodiesterase (NPP1)

The present invention provides a method of treating NPP1 deficiency or NPP1-associated disease such as idiopathic infantile arterial calcification (IIAC), pseudoxanthoma elasticum, vascular calcification in chronic kidney disease (VCCKD), insulin resistance, hypophosphatemic rickets, myocardial ischemia, joint calcification, angioid streaks, and ossification of the posterior longitudinal ligament of the spine. The present invention provides a method for treating tissue calcification by administering soluble NPP1 to produce a transient increase in serum pyrophosphate levels.

Methods of treating tissue calcification

The present invention provides a method of treating myointimal proliferation by administering a recombinant human soluble ectonucleotide pyrophosphatase phosphodiesterase (hsNPP1), active fragment or fusion protein thereof.

Methods of treating myointimal proliferation

Methods for treating the central nervous system (CNS) in a human patient with mucopolysaccharidosis (MPS) MB who has an intact blood brain barrier, comprising intravenous administration of recombinant NaGlu.

Methods of treating Mucopolysaccharidosis IIIB (MPSIIIB)

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Lincoln, MA, United States of America

Kim Lynette Askew