Kimberly-clark Worldwide, Inc.

Kim LaRae Resheski-Wedepohl

Rae Ellen Syverson

Ali Yahiaoui

Shannon Kathleen Melius

David Charles Potts

Valerie Victoria Finch

Rebecca Lyn Dilnik

Matthew David Young

Patricia Ann Samolinski

Janet Jessie Larsen

Scott Richard Martin

Mary Watt Goggans

A method to inhibit the production of exoproteins from Gram positive bacteria, such as harmful proteins produced byspecies, is described. The method is particularly useful to inhibit the production of TSST-1, alpha-toxin and/or enterotoxins A, B and C frombacteria. The method is based on exposing Gram positive bacteria to alkyl polyglycoside incorporated into an absorbent product. Alternate methods include bringing Gram positive bacteria into contact with the alkyl polyglycoside in other forms, e.g., when formulated with a pharmaceutically acceptable carrier or incorporated in or on a non-absorbent substrate. Typically, the alkyl polyglycoside has a hydrophilic/lipophilic balance (HLB) of at least about 10 and an alkyl group with an average of 8 to 14 carbon atoms.

Method to produce a tampon that inhibits exoprotein production from gram positive bacteria

A package () of articles comprises a bottom panel (), and a top panel (). The top panel is operatively positioned and joined with the bottom panel () to provide a closed package. The top panel () is appointed to face toward a user, and a plurality of personal care articles () are contained in the package (). The package () includes an opening mechanism () which provides access to the articles (), and each article includes a liquid-permeable topsheet layer (), and a backsheet layer (). A data layer () is operatively joined to the article (), and is intended to be selectively repositioned prior to using the article, to enable full functionality of the article. Data indicia () are located on the data layer () and configured to communicate a message to the user. The message can be related to at least one of motivating the user, entertaining the user, educating the user, and inspiring the user. Each article () is positioned in the package () with its data layer () arranged to face toward the user when the article () is first presented to the user upon removal through the opening mechanism ().

Package having an opening mechanism and containing selectively oriented absorbent articles

Non-absorbent substrates for use in inhibiting the production of exoproteins from Gram positive bacteria, such as harmful proteins produced by Staphylococcus species, are provided. The substrates are particularly useful for inhibiting the production of TSST-1, alpha-toxin and/or enterotoxins A, B and C from bacteria. The substrates include an alkyl polyglycoside incorporated in or on at least a portion of the substrate. The alkyl polyglycoside typically has an HLB of about 10 to 15 and/or an average number of carbon atoms in the alkyl chain of about 8 to about 12.

Non-absorbent substrates for the inhibition of exoprotein production from gram positive bacteria

A method of inhibiting the production of exoproteins from Gram positive bacteria, such as harmful proteins produced by Staphylococcus species, is described. The method is particularly useful for inhibiting the production of TSST-1, alpha-toxin and/or enterotoxins A, B and C from bacteria. The method may be based on exposing Gram positive bacteria to alkyl polyglycoside incorporated into an absorbent product. Alternatively, the methods can include causing Gram positive bacteria to come into contact with the alkyl polyglycoside in other forms, e.g., when formulated with a pharmaceutically acceptable carrier or incorporated in or on a non-absorbent substrate. Typically, the alkyl polyglycoside has an HLB of at least about 10 and an alkyl group with an average of 8 to 14 carbon atoms.

Inhibition of exoprotein production from gram positive bacteria

An absorbent article for inhibiting the production of exoproteins from Gram positive bacteria, such as potentially harmful proteins produced by Staphylococcus species, is described. The absorbent article is particularly useful for inhibiting the production of TSST-1, alpha-toxin and/or enterotoxins A, B and C from bacterium. An alkyl polyglycoside is incorporated into the absorbent article. For example, alkyl polyglycoside may be coated on the fibers of a liquid-permeable cover of a catamenial tampon.

Absorbent articles for the inhibition of exoprotein production from Gram positive bacteria

Compositions for use in inhibiting the production of exoproteins from Gram positive bacteria, such as harmful proteins produced by Staphylococcus species, are described. The compositions are particularly useful for inhibiting the production of TSST-1, alpha-toxin and/or enterotoxins A, B and C from bacteria. The compositions include alkyl polyglycoside and a pharmaceutically acceptable carrier. The alkyl polyglycoside typically has an HLB of at least 10 and/or an average number of carbon atoms in the alkyl chain of 8 to 12.

Compositions for the inhibition of exoprotein production from Gram positive bacteria

Disclosed is an absorbent article having an absorbent core. The absorbent core includes a primary absorbent member and a secondary absorbent member. The primary absorbent member has a fluid distribution rate, expressed as the ratio of a stain area in the primary absorbent member to a stain area in the secondary absorbent member, along a X-Y direction greater than about 1.8 times faster than the secondary absorbent member. The fluid distribution rate is expressed as a ratio of a stain area in the primary absorbent member to a stain area in the secondary absorbent member five minutes after a given volume of test fluid insults the absorbent core. The secondary absorbent member has a substantial portion thereof composed of a non-absorbent polymeric composition. The secondary absorbent member is superposed over a portion of the primary absorbent member. In a preferred embodiment, the secondary absorbent member has an aperture or orifice having an open surface area greater than about 20% of the secondary absorbent member surface area.

Growing community of inventors

Reedsville, WI, United States of America

Kim LaRae Resheski-Wedepohl