Supercritical Fluid Technologies, Inc.

Other

The Boeing Company

University of Delaware

Accudyne Systems, Inc.

Kim Ferrara

Curtis Ebersold

Brian Jeffrey Waibel

Kenneth Joseph James

Kenneth Richard Krewson

Ralph Douglas Cope

Steven Andrew Cope

Nanette Gopez

Thomas Jacob Hagman

Michael G Case

James Cole Galloway

Jesse C Brown

Tracy Dolan

Steven A Cope

Tim Braucht

Ross Hutter

Provided is a high-pressure fluid chromatography system using interior-to-exterior column pressure equalization, and components comprising such a system, including a pressure equalizing vessel which allows for the use of an inner chromatography column that is only able to withstand an interior-to-exterior pressure differential of up to 200 psi.

High-pressure fluid chromatography system using interior-to-exterior column pressure equalization

A chromatography system has a cartridge adapter that is detachably attachable to enable a chromatography cartridge to be quickly interchanged. Chromatography cartridges are configured with threads for coupling to a corresponding interchangeable coupling component having matching threads. The interchangeable coupling component may be secured to the chromatography system by a coupling retainer. A coupling retainer may have a keyway that is configured for quick interchanging of the interchangeable coupling components. The interchangeable coupling component may have a pair of parallel sides that align with a slot of the keyway to secure the interchangeable coupling components to the coupling retainer. An inlet nipple of the chromatography cartridge may extend through an opening in the coupling components and couple to an inlet conduit for sample gas. Analyte gas may flow back to the chromatography system for detection and collection.

Interchangeable chromatography cartridgeadapter system

Provided is a chiller and system that may be utilized in a supercritical fluid chromatography method, wherein a non-polar solvent may replace a portion or all of a polar solvent for the purpose of separating or extracting desired sample molecules from a combined sample/solvent stream. The system may reduce the amount of polar solvent necessary for chromatographic separation and/or extraction of desired samples. The system may incorporate a supercritical fluid chiller, a supercritical fluid pressure-equalizing vessel and a supercritical fluid cyclonic separator. The supercritical fluid chiller allows for efficient and consistent pumping of liquid-phase gases employing off-the-shelf HPLC pumps. The pressure equalizing vessel allows the use of off-the-shelf HPLC column cartridges. The system may further incorporate the use of one or more disposable cartridges containing silica gel or other suitable medium. The system may also utilize an open loop cooling circuit using fluids with a positive Joule-Thomson coefficient.

Cooling loop with a supercritical fluid system using compressed refrigerant fluid flow with a positive Joule Thomson coefficient

Provided is a chiller and system that may be utilized in a supercritical fluid chromatography method, wherein a non-polar solvent may replace a portion or all of a polar solvent for the purpose of separating or extracting desired sample molecules from a combined sample/solvent stream. The system may reduce the amount of polar solvent necessary for chromatographic separation and/or extraction of desired samples. The system may incorporate a supercritical fluid chiller, a supercritical fluid pressure-equalizing vessel and a supercritical fluid cyclonic separator. The supercritical fluid chiller allows for efficient and consistent pumping of liquid-phase gases employing off-the-shelf HPLC pumps. The pressure equalizing vessel allows the use of off-the-shelf HPLC column cartridges. The system may further incorporate the use of one or more disposable cartridges containing silica gel or other suitable medium. The system may also utilize an open loop cooling circuit using fluids with a positive Joule-Thompson coefficient.

Supercritical fluid chromatography system

Provided is a supercritical fluid chromatography method, system, and components comprising such a system wherein a non-polar solvent may replace a portion or all of a polar solvent for the purpose of separating or extracting desired sample molecules from a combined sample/solvent stream. The method and system are designed to eliminate or reduce the amount of polar solvent necessary for chromatographic separation and/or extraction of desired samples to less than or equal to twenty percent polar solvent within the total volume concentration of the total solvents used, and the technique may include one or more of a supercritical fluid chiller, a supercritical fluid pressure-equalizing vessel, and a supercritical fluid cyclonic separator. The supercritical fluid chiller and the use of the chiller allow efficient and consistent pumping of liquid-phase gases employing off-the-shelf HPLC pumps in the supercritical chromatography system using liquid-phase gas mobile phase. The pressure equalizing vessel allows the use of off the shelf HPLC column cartridges in the supercritical chromatography system. The cyclonic separator efficiently and effectively allows for separation of sample molecules from a liquid phase or gas phase stream of a supercritical fluid. The technique may further incorporate the use of one or more disposable cartridges containing silica gel or other suitable medium for use as a chromatographic separation column. The technique may also utilize an open loop cooling circuit using fluids with a positive Joule-Thompson coefficient.

Systems and methods for supercritical fluid chromatography

A hail producing machine includes at least one diffuser for mixing water and carbon dioxide. At least one heat exchanger is in flow communication with the diffuser for receiving the mixture. A refrigeration unit freezes the mixture to form an ice rod in the heat exchanger. The ice rod is ejected from the heat exchanger and is converted into hail stones by a molding station downstream from the heat exchanger.

Hail producing machine

A gantry system supports a human user in a harness attached to a carriage on a track. The carriage may comprise a body defining a U-shaped or C-shaped opening sized to receive a cylindrical track, and a pair of wheels attached to the body that roll along a top portion of the track with sufficiently minimal drag to permit the user to move the carriage without assistance. Single track embodiments may have a straight or curved trajectory and may have intersecting track portions with junctions that move between the intersecting track portions. In other embodiments, the carriage traverses a perpendicular track spanning a pair of parallel tracks. The perpendicular track may traverse the parallel tracks with or without motorized assistance. A counterweight system may provide partial weight support for the user. In one embodiment, the tracks are supported by a collapsible free-standing structure.

Open area harness system for providing patient mobility

An apparatus for splicing an elongate multi-layered workpiece includes: (a) drives and guides cooperating to drive the workpiece along a working path; (b) a cutter for severing the workpiece; (c) a layer manipulator for separating layers; (d) an applicator for applying adhesive; and (e) a deflector unit for deflecting the workpiece from the working path. The cutter effects the severing to present first and second workpiece segments. The layer manipulator effects inter-layer separation in one segment to present an interlayer zone in the one segment. A drive inserts the other segment in the interlayer zone. The layer manipulator urges the layers together to capture the other segment within the interlayer zone to establish a multi-layer structure. A drive and at least one of the workpiece deflector unit and the applicator situate the multi-layer structure adjacent to the applicator for finishing the splicing by applying adhesive to the multi-layer structure.

Growing community of inventors

Middletown, DE, United States of America

Kim Ferrara