University of California

University of Pennsylvania

Killian Oukoloff

Amos B Smith, Iii

Virginia Man-Yee Lee

John Q Trojanowski

Carlo Ballatore

Kurt R Brunden

The present disclosure provides compounds of formula (I) or (II) or a pharmaceutically acceptable salt or stereoisomer thereof, wherein Rx-R8 are defined herein. Also provided are compositions comprising a compound described herein and a pharmaceutically effective excipient, methods of stabilizing microtubules in a patient comprising administering to the patient a microtubule-stabilizing amount of a compound described herein, methods of treating cancer in a patient comprising administering to the patient a therapeutically effective amount of a compound described herein, and methods of treating a neurodegenerative disease in a patient comprising administering to the patient a therapeutically effective amount of a compound described herein. 

Growing community of inventors

San Diego, CA, United States of America

Killian Oukoloff