Wisconsin Alumni Research Foundation

Fujifilm Cellular Dynamics, Inc.

Kile Patrick Mangan

Mathew Victor Jones

Aaron B Nelson

Chiara Cirelli

Coby B Carlson

In some aspects, cultures of neurons derived from human induced pluripotent stem cells (iPS cells) that exhibit synchronous firing of neural networks are provided. In some embodiments, neuronal activity of the cultures may be detected or measured using a multi-electrode array.

Neural networks formed from cells derived from pluripotent stem cells

Absence epilepsy, a form of epilepsy characterized by nonconvulsive seizures, has proven to be refractive to conventional epilepsy therapies. It has been found that low doses of ganaxolone can be used to reduce absence seizures in subjects with absence epilepsy, particularly pediatric subjects. In addition, ganaxolone therapy is particularly useful in subjects with absence epilepsy characterized by a reduction in tonic inhibition. Low dose ganaxolone is also used to reduce sleep disruptions and to treat sleep disorders in subjects in need of such treatment.

Growing community of inventors

Madison, WI, United States of America

Kile Patrick Mangan