Orchid Chemicals & Pharmaceuticals Limited

Kilambi Narasimhan

Sriram K Rajagopal

Ravikumar Tadiparthi

Gopalan Balasubramanian

Shridhar Narayanan

Venkatesan Parameswaran

Virendra Kachhadia

Ganapavarapu Veera Raghava Sharma

Uma Ramachandran

Sanjeev Saxena

Sukunath Narayanan

Maruthikumar Narayanam

Sathyanarayana Gadde

Durairaj Peter Bhakiaraj

Sathya Narayana Thara

Venkatesan Janarthanam

Narayanan Surendran

Visweswara Akella Satya Surya Srinivas

Lolaknath Santosh Vishwakarma

Thirunavukkarasu Sappanimuthu

Om Reddy Gaddam

Described are novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof. These compounds are useful in the treatment of immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; atherosclerosis; cancer; cachexia; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; ARDS; psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; asthma; COPD; bone resorption diseases; multiple sclerosis; sepsis; septic shock; toxic shock syndrome and fever. More particularly these compounds are useful as PDE4 inhibitors and are useful for treating PDE4 mediated diseases. 

Pyrimidine compounds and their uses

Growing community of inventors

Chennai, India

Kilambi Narasimhan