Toyo Jozo Kabushiki Kaisha

Toyo Jozo Company, Ltd.

Kikuo Kotani

Nobuaki Nakagawa

Tadashiro Fujii

Kunio Ohyama

Susumu Watanabe

Toshiharu Noda

Shigeo Katsuragi

Kaoru Morita

Ken Endo

Hitoshi Yamada

Tsuneo Okuyama

The present invention provides an aqueous solution composition containing elcatonin as an active ingredient used for hypercalcemia or bone Paget's disease or improvement of pain in osteoporosis, etc. and which is highly stable against shaking, light and heat. This composition contains an effective amount of elcatonin as an active ingredient and a monocarboxy compound and/or its water soluble salt thereof in a molar concentration of 0.05-20 mmol and has a pH of 5.0-6.5 and an ionic strength of .mu.=0.01-0.5. Preferred examples of the monocarboxy compound and its salts are acetic acid, lactic acid, L-histidine, sodium acetate, potassium acetate, sodium lactate, potassium lactate and L-histidine hydrochloride.

Aqueous elcatonin solution composition

Process for the preparation of antibodies

A polyfunctional disulfide compound, useful as a cross-linking reagent having S--S exchange reactivity, of the formula ##STR1## wherein R is 2-benzothiazolyl or 2-pyridyl-N-oxide and X is a spacer group having an alkylene group directly bonded to each S--S group.

Polyfunctional disulfide compounds having S--S exchange reactivity

A disulfide derivative, having S--S exchange reactivity, of the formula

Disulfide derivatives having S--S exchange reactivity

A disulfide compound of a carrier, having S--S exchange reactivity, of the formula

Disulfide compounds of a carrier, having S--S exchange reactivity

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Shizuoka, Japan

Kikuo Kotani