Ono Pharmaceutical Co., Ltd.

Kigen Kondo

Yoshitaka Konishi

Sung J Lee

Dingwei Tim Yu

Orest Taras Macina

Manton Rodgers Frierson

Masafumi Sugitani

Tamara A Miskowski

The compounds of the formula: ##STR1## wherein Y is bond or alkylene;

Heterocyclic compounds

The compounds of the formula: ##STR1## wherein ring ##STR2## is a hetero ring containing nitrogen atom, optionally selected from ##STR3## n is 0-2; Y is bond or alkylene;

Fused pyrimidines and pyriazines as pharmaceutical compounds

A 4-aminopyrimidine of the formula (I): ##STR1## wherein A is a bond, C1-4 alkylene or C1-4 oxyalkylene;

4-aminopyrimidine derivatives

The compounds of the formula: ##STR1## wherein R.sup.1, Y, A, Z, CyB, R.sup.3, R.sup.4, n and m are described in the specification and claims. and acid addition salts thereof, salts thereof, and hydrates thereof; have inhibitory effect on cGMP-PDE, and additionally on TXA.sub.2 synthetase.

4-aminoquinazoline derivatives

The compounds of the formula: ##STR1## wherein R.sup.1, Y, A, R.sup.4, n, Z, CyB, R.sup.3, and m are defined in the specification.

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Osaka, Japan

Kigen Kondo