480 Biomedical Inc.

Tepha, Inc.

Arsenal Medical, Inc.

Lyra Therapeutics, Inc.

Kicherl Ho

Lee A Core

Maria Palasis

Upma Sharma

Changcheng You

Gregory T Zugates

Danny Concagh

David P Martin

Simon F Williams

Said Rizk

Rany Busold

Daniel Concagh

Nareak Douk

Timothy Robinson

Amit Ganatra

Greg Zugates

Chang Cheng You

My Le

Jerry Brightbill

Benedict Shia

Kai Guo

Sarah Kostanski

Ryan Cahil

Disclosed are self-expanding medical implants for placement within a lumen of a patient. The implants comprise a woven or non-woven structure having a substantially tubular configuration, and are designed to be low-profile such that they are deliverable with a small diameter catheter. The implants have a high recoverability and desired mechanical properties.

Drug eluting medical implant

Drug-eluting medical implants

Continuous processing methods for making absorbable polymeric dry spun non-wovens with one or more of the following properties: high burst strength, fine fibers of average diameter from 0.01 &#x3bc;m to 50 &#x3bc;m, and thickness from 10 &#x3bc;m to 10 mm, have been developed. Improved fiber cohesion is made possible by controlling the tackiness of the fibers of the non-woven during web collection. The polymer is preferably a polyhydroxyalkanoate, more preferably, a 4-hydroxybutyrate polymer or copolymer. A non-woven of poly-4-hydroxybutyrate is most preferred. The non-wovens have fine fibers with average diameters ranging from 0.01 &#x3bc;m to 50 &#x3bc;m, and are derived by dry spun processing, during which a solution of polymer(s) is injected into a stream of high velocity air with a pressure of 1 to 500 psi for solvent stripping and polymer strand attenuation. The non-wovens can be used for a variety of purposes including fabrication of medical devices.

Medical devices containing dry spun non-wovens of poly-4-hydroxybutyrate and copolymers

Disclosed is a self-expanding medical implant for placement within a lumen of a patient. The implant comprises a woven or non-woven structure having a substantially tubular configuration, and is designed to be low-profile such that it is deliverable with a small diameter catheter. The implant has a high recoverability and desired mechanical properties.

Medical implant

Delivery systems for a polymeric tubular implant, kits that include such delivery systems, and methods of treating patients by implanting tubular implants using the delivery systems. The delivery systems include an inner shaft, an expandable member slidably disposed about the inner shaft and configured to receive the tubular implant, and a tubular outer shaft disposed about the inner shaft.

Polymeric implant delivery system

Medical implants

Continuous processing methods for making absorbable polymeric films with one or more of the following properties: high toughness, low modulus, high tensile strength, and thickness less than 10 mm, more preferably less than 1 mm, and more preferably less than 100 &#x3bc;m, have been developed. In the preferred embodiment, the polymer is a polyhydroxyalkanoate, and in the most preferred embodiment, the polymer comprises 4-hydroxybutyrate. A particularly preferred embodiment is a film of poly-4-hydroxybutyrate or copolymer thereof, wherein the film has a tensile strength greater than 5.5 kgf/mm, tensile modulus less than 181 kgf/mm, and elongation at break from 10-500%, wherein the film is derived by a continuous process such as melt extrusion or solvent casting, followed by orientation to more than 25% of the film's original length in one or more directions. These can be used for a variety of purposes including fabrication of medical devices.

Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers

Continuous processing methods for making absorbable polymeric non-wovens with one or more of the following properties: high burst strength, fine fibers of average diameter from 1 &#x3bc;m to 50 &#x3bc;m, and thickness from 10 &#x3bc;m to 50 mm, have been developed. Improved fiber cohesion is made possible by allowing the fibers of the non-woven to initially remain molten during web collection. In the preferred embodiment, the polymer is a polyhydroxyalkanoate, and in the most preferred embodiment, the polymer comprises 4-hydroxybutyrate. A particularly preferred embodiment is a non-woven of poly-4-hydroxybutyrate or copolymer thereof, wherein the non-woven has a burst strength greater than 0.1 Kgf, wherein the non-woven is derived by a continuous melt-blown process. The non-wovens can be used for a variety of purposes including fabrication of medical devices.

Medical devices containing melt-blown non-wovens of poly-4-hydroxybutyrate and copolymers thereof

Growing community of inventors

Groton, MA, United States of America

Kicherl Ho