Samsung Sds Co., Ltd.

Autotac Inc.

Seoul National University

Ki Woon Sung

Kyu Sang Lee

Yong Tae Kwon

Chan Hoon Jung

Srinivasrao Ganipisetti

Su Ran Mun

Eui Jung Jung

Chang Hoon Ji

Hee Yeon Kim

Chang Suk Yoon

Sang Won Lee

SAng Hyeon Kang

Jae Seok Lee

Su Jin Kim

Ji Eun Lee

Kyung Jin Kim

Jung Woo Cho

Hyo Jung Lee

Hyun Tae Kim

Young Yoo Heo

Chang Min Park

Min Ju Lee

Seung Woo Nam

Han Saem Seo

Sang Ji Bae

Hwa Yong Oh

Hyung Joo Mo

Eil Woo Baik

Eun Hye Jeong

Tae Hyun Bae

Hwa Yong Yoon

The present invention relates to a novel p62 ligand compound, a stereoisomer, hydrate, solvate or prodrug thereof, and a pharmaceutical or food composition for preventing or treating misfolded protein diseases comprising the same as an active ingredient. The p62 ligand compound according to the present invention can be usefully used as a pharmaceutical composition for the prevention, amelioration or treatment of various proteinopathies by activating selective autophagy in cells and thus selectively eliminating in vivo proteins, organelles and aggregates.

P62 ligand compound, and composition for preventing, ameliorating or treating proteinopathies comprising the same

One aspect of the disclosure relates to a cargo delivery system comprising an autophagy targeting ligand and a target-binding ligand. In one aspect of the disclosure, by comprising an autophagy targeting ligand, cargo, which is a target-binding ligand that specifically binds to a target, is delivered to the p62 protein and autophagy is activated, so that depending on the type of target-binding ligand used, a target to be degraded can be selectively and directly removed. Accordingly, the cargo delivery system according to an aspect of the disclosure may be used in pharmaceutical compositions or food compositions for preventing, alimerating, and treating various diseases.

Cargo delivery system and composition comprising the same

The present invention relates to a novel AUTOTAC chimeric compound in which a new p62 ligand and a target-binding ligand are connected by a linker, a stereoisomer, hydrate, solvate or prodrug thereof, and a pharmaceutical or food composition for the prevention or treatment of diseases by degrading the target protein including the same as an active ingredient. They can target specific proteins to adjust their concentrations, and can also deliver drugs and other small molecule compounds to lysosomes. The AUTOTAC chimeric compound according to the present invention can be usefully used as a pharmaceutical composition for the prevention, amelioration or treatment of various diseases by selectively eliminating specific proteins.

AUTOTAC chimeric compound, and composition for preventing, ameliorating or treating diseases through targeted protein degradation comprising the same

The present invention provides a compound represented by the following Chemical Formula 1 or a pharmaceutically acceptable salt thereof which can be effectively used for preventing or treating obesity or metabolic syndrome, and a pharmaceutical composition comprising the same.

Compound and pharmaceutical composition for preventing or treating obesity or metabolic syndrome comprising thereof

The present invention relates to a novel p62 ligand compound, a stereoisomer, hydrate, solvate or prodrug thereof, and a pharmaceutical or food composition for preventing or treating proteinopathies comprising the same as an active ingredient. The p62 ligand compound according to the present invention can be usefully used as a pharmaceutical composition for the prevention, amelioration or treatment of various proteinopathies by activating autophagy in cells and thus selectively eliminating in vivo proteins, organelles and aggregates.

A method for batch processing for a plurality of individual transactions includes generating a batch transaction by aggregating at least some of the plurality of individual transactions according to a setting value of a batch size, and processing the batch transaction via a blockchain network. The generation of the batch transaction includes adjusting the setting value of the batch size based on a monitoring result for a transaction processing status, and generating the batch transaction according to the adjusted setting value.

Apparatus and method for batch processing for blockchain transactions

An accelerated transaction processing apparatus includes a memory for storing one or more instructions, a communication interface for communicating with a blockchain network, and a processor. The processor is configured to determine whether the blockchain network is in a congested state based on monitoring information about the blockchain network, adjust a batch size based on a result of the determination, and perform batch processing for one or more individual transactions using the adjusted batch size.

Accelerated processing apparatus for transaction and method thereof

A data management system according to an embodiment of this invention includes a blockchain node configured to store on-chain data on blockchain and a service server, upon receiving a service request associated with the original data from a client, i) accessing off-chain data stored in a storage node or recording off-chain data in the storage node according to the service request, and ii) sending a transaction proposal to the blockchain node for a record associated with the service request to be stored in the blockchain.

Blockchain based data management system and method thereof

A method of sharing information on the basis of anchoring and an anchoring device supporting the same and more particularly are provided. One of the methods includes, acquiring anchoring information including first field information permitted for sharing from a target transaction record recorded in a first blockchain and recording the acquired anchoring information in a second blockchain.

Method and apparatus for sharing information recorded on blockchain based on anchoring

A file transmission method includes storing each chunk of a target file by public cloud, receiving, by the first node, a file transmission request including an encrypted chunk order sheet of the target file, information on the target file and recipient information, wherein the chunk order sheet includes connection order information of each chunk necessary for restoring the target file, and the encrypted chunk order sheet is encrypted with a public key of a recipient, storing a first transaction including information included in the file transmission request and chunk storage location information in a ledger stored in the first node, storing, by the second node, the first transaction in a ledger of the second node according to synchronization of the ledger, storing a chunk in the internal storage using the chunk storage location information when the recipient information included in the first transaction includes a user belonging to the intranet.

Blockchain based file management system and method thereof

Provided is a video analysis (VA) method comprises calculating, by a VA apparatus, a size of each of a plurality of frames by summing sizes of a plurality of packets constituting each of the plurality of frames, analyzing, by the VA apparatus, the size of each of the plurality of frames constituting a video to determine a pattern of the sizes of the plurality of frames and determining, by the VA apparatus, whether there is a motion in the video based on the size pattern.

Video analysis method and apparatus and computer program

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Seoul, South Korea

Ki Woon Sung