Celltrion Inc.

Samsung Electro-mechanics Co., Ltd.

Ki Sung Kwon

Shin Jae Chang

Kye Sook Yi

Yoo Hwan Kim

Soo Woong Lee

Yo Sub Moon

Hyun Joo Lee

Min Seok Chang

Jin Taek Lee

Sung Cheol Shin

Hwang Keun Jun

Jae Won Jeon

Jae Won Lee

Sung Hwan Kim

Gyu Suck Kim

Seung Suh Hong

Dong Woo Lee

So Jung Lee

Yeon Jung Kim

Myung Sam Cho

Ji Young Shin

Dong Rim Yeom

Byoung Oh Kwon

Mi Na Song

Eun Beom Lee

The present invention provides a composition comprising at least two influenza A virus-neutralizing binding molecules that bind to an epitope in the stem region of influenza A virus hemagglutinin (HA) protein, the method comprising: i) a first binding molecule capable of neutralizing at least one influenza A virus subtype selected from the group consisting of H1, H2, H5 and H9; ii) a second binding molecule capable of neutralizing at least one influenza A virus subtype selected from the group consisting of H1, H3, H5, H7 and H9. The mixed composition of the present invention can effectively neutralize the multiple influenza subtypes of both phylogenetic group 1 and phylogenetic group 2 and can be used in combination with a chemical compound. Thus, the composition of the present invention is very useful for the prevention and treatment of a disease by influenza virus.

Composition comprising at least two influenza A virus-neutralizing-binding molecules

The present invention relates to a method for separating antibody isoforms using cation exchange chromatography and, more specifically, to a method for separating and purifying several isoforms, which are generated during an antibody production procedure, using a washing buffer for cation exchange chromatography.

Method for separating antibody isoforms using cation exchange chromatography

The present invention relates to a binding molecule having influenza A virus-neutralizing activity derived from a human B cell, and the binding molecule having the influenza A virus-neutralizing activity, according to the present invention, is a binding molecule that is derived from a B cell that is selected from the blood of a patient infected with an influenza A virus, and has neutralizing activity against influenza A viruses, and thus is useful in preventing and treating disease derived from the influenza A virus, and can be useful in diagnosing the influenza A virus by using the binding molecule according to the present invention.

Binding molecule having influenza A virus-neutralizing activity produced from human B cell

A phase frequency detector for improving in-band phase noise characteristics of a PLL is disclosed. The phase frequency detector compares a reference frequency with a division frequency created by dividing an output frequency of a voltage controlled oscillator (VCO) by a predetermined division ratio, creates a phase-difference signal corresponding to a phase difference between the reference frequency and the division frequency, and improves noise characteristics.

Phase frequency detector capable of improving noise characteristics

The invention provides a low divide ratio programmable frequency divider of a fractional-N type applied to a digital MOPLL tuner and a method thereof. In the invention, a divide ratio assigner assigns divide data as a main divide ratio and a pulse swallow value according to a first or a second dividing operation mode in response to a mode selection signal. A prescaler operates on the first or second divide operation mode in response to the mode selection signal. Also, a main counter divides a frequency from the prescaler by the main divide ratio. Further, a pulse swallow counter counts a clock of the main counter while outputting a pulse swallow signal to the prescaler. The pulse swallow signal has a swallow level if a counting value corresponds to the pulse swallow value, and a non-swallow level if the counting value does not correspond to the pulse swallow value.

Low divide ratio programmable frequency divider and method thereof

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Seoul, South Korea

Ki Sung Kwon