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Korea Advanced Institute of Science and Technology

Intelligent Synthetic Biology Center

Ki Jun Jeong

Sang Yup Lee

Sun Chang Kim

So Young Yoo

Shi Chen

Ki Chang Keum

Zixin Deng

Hyun Cheol Chung

Suk Chae Jung

Won Min Yoo

Yoon Hyeok Lee

Nae Choon Yoo

Hyun Bae Bang

Xiufen Zhou

Provided is a method of preparing cinnamaldehyde by using a recombinant microorganism.

Method of preparing cinnamaldehyde

Disclosed are a method, a composition, a microarray, an antibody and a kit for diagnosis and prognosis of cancer, based on detection of deletion of the exon 3 region of G-CSF gene or levels of a mutated G-CSF protein having a deletion of an amino acid sequence corresponding to the exon 3 region, wherein the deletion of the exon 3 region of the G-CSF gene is used as a cancer biomarker.

Microarray for detection of the deletion of exon 3 of the G-CSF gene

The present invention relates to the base sequence of whole genes involved in the biosynthesis of FR-008 polyketides derived fromsp. FR-008. This base sequence comprises genes coding for ketosynthase (KS), acyl transferase (AT), acyl carrier protein (ACP), ketoreductase (KR), dehydratase (DH) and enoyl reductase (ER) domains, and genes coding for modifier enzymes, such as ABC transporter, cytochrome P450 monooxygenase, ferredoxin, thioesterase, sugar synthetic protein, FAD-dependent monooxygenase, 4-amino-4-deoxychorismate (ADC) synthase and ADC lyase. The gene base sequence according to the present invention can be used to increase the productivity of the existing FR-008 polyketides or produce new FR-008 polyketides, through modification of its parts.

Genes for synthesis of FR-008 polyketides

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Daejeon, South Korea

Ki Jun Jeong