Industry-academic Cooperation Foundation Gyeongsang National University

Seoul National University

Snu Rdb Foundation

Gwangju Institute of Science and Technology

Korea Research Institute of Bioscience and Biotechnology

Industry-academic Cooperation Foundation

Ki Hun Park

Hyung Won Ryu

Young Bae Ryu

Jung Weon Lee

Woo Song Lee

Ji Yun Yoo

Soojong Park

Yeong Hun Song

Kwang Dong Kim

Sangseok Oh

Kiwon Lee

Sin-Ae Lee

Tae-Sook Jeong

Myung-Sook Choi

Ho Yong Park

Hyung-Jae Jeong

Jong-Min Han

Soo Hyun Eom

Jin Hyo Kim

Woo Duck Seo

Jung Keun Cho

Sang Wan Gal

Heung Joo Yuk

Yeong Jun Ban

Min Kyung Kang

Jeong Ho Kim

Dae Wook Kim

A skin whitening composition includes β-mangostin or a cosmetically acceptable salt thereof as an effective ingredient. β-Mangostin represented by Chemical Formula 1 suppresses the expression of tyrosinase and TRP-1 (tyrosinase-related protein-1) and induces autophagy of a melasosome. As such, it was confirmed that the β-mangostin not only suppresses melanin production but also exhibits the effect of removing previously formed melanin. Accordingly, the β-mangostin can be advantageously used as a functional material for skin whitening and skin lightening.

Composition for skin whitening comprising β-mangostin as effective ingredient

The present invention relates to a method for preparation of soybean leaves having a high content of an isoflavone derivative in a dark condition and soybean leaves having a high content of an isoflavone derivative prepared thereby. Specifically, treatment of a soybean plant 20 days to 60 days after seeding with a predetermined concentration of ethylene in a dark condition was found to accumulate higher concentrations of isoflavone derivatives in soybean leaves than treatment with ethephon in a light condition, which requires a high level of energy. Therefore, when used, the method of the present invention can economically and quickly prepare soybean leaves having a very high content of isoflavones, and the soybean leaves having a high content of isoflavone derivatives, an extract of the soybean leaves, and a fraction of the extract can be advantageously used as a food and medicine material against diseases caused by estrogen unbalance and deficient antioxidant activity.

Method for preparation of soybean leaf having high content of isoflavone derivative in dark condition and soybean leaf having high content of isoflavone derivative prepared thereby

A skin whitening composition includes amorphigeni or a salt thereof as an effective ingredient. Amorphigeni suppresses the expression of tyrosinase and induces autophagy on melanosomes. As such, it was confirmed that amorphigeni not only suppresses melanin production but also exhibits the effect of removing melanin previously produced by &#x3b1;-MSH (melanocyte-stimulating hormone). Accordingly, amorphigeni can be advantageously used as a functional material for skin whitening and skin lightening.

Composition for skin whitening comprising amorphigeni as effective ingredient

The present invention relates to a composition for suppressing neuraminidase activity comprising a geranylated flavonoid derived fromas an active ingredient. Theextract and the geranylated flavonoid isolated therefrom exhibit an effect in significantly suppressing neuraminidase, which is an enzyme that plays an important role in the occurrence of pathogenic viral and bacterial infections and of the inflammation that accompanies such infection, and thus theextract or the geranylated flavonoid isolated therefrom can advantageously be used as an active ingredient in a composition for inhibiting neuraminidase activity.

Composition for suppressing neuraminidase activity comprising geranylated flavonoid derived fromas active ingredient

The present invention relates to soybean leaves or soybean stems having high isoflavone derivative content, and a method for preparing the same. Specifically, by finding that soybean leaves or soybean stems treated with ethylene and ethephon, i.e. a ethylene donor, show significantly increased isoflavone derivative content, the method for preparing the soybean leaves or soybean stems having high isoflavone derivative content and the soybean leaves or soybean stems having high isoflavone derivative content prepared by using the method can be useful as functional foods and medicinal materials for diseases due to estrogen imbalance and lack of the antioxidative activity.

Bean leaves or bean stems having high isoflavone derivatives content and method for preparing same

The present invention relates to compositions for preventing and treating obesity, hyperlipidemia, atherosclerosis, fatty liver, diabetes or metabolic syndrome containing extracts ofleaves or fractions isolated from the same.

Compositions for preventing and treating obesity, hyperlipidemia, atherosclerosis, fatty liver, diabetes or metabolic syndrome containing extracts of glycine max leaves or fractions isolated from the same as an active ingredient

The present invention relates to a method for screening an anticancer compound and an anticancer compound screened using the method, and more particularly, to a method for screening an anticancer compound, the method comprising: culturing cancer cells expressing the oncogenic protein transmembrane 4 L6 family member 5 (TM4SF5), expressed as the polypeptide of SEQ ID NO: 2, treating the cancer cells with an anticancer candidate, and determining that the anticancer candidate is an anticancer substance when the candidate exhibits antagonistic activity against tumor formation and metastasis based on several events through the molecular mechanism of TM4SF5. The present invention also relates to chalcone compounds screened to have anticancer activity using the method, and an anticancer composition comprising the compound as an effective ingredient.

Method for screening anti-cancer compounds inhibiting function of TM4SF5 and anti-cancer composition containing chalcone compounds

A composition for diagnosing, treating, and preventing liver disease, more particularly a composition for diagnosing liver disease comprising a material for measuring the grade of TM4SF5 (transmembrane 4 L six family member 5 or four-transmembrane L6 superfamily member 5) protein, a kit for diagnosing liver disease comprising the composition, a method for providing information necessary for diagnosing liver disease composed of the following steps: measuring the level of TM4SF5 protein and the expressions and phosphorylations of TM4SF5 expression related signaling proteins; and comparing the measured levels with those of the normal control, a method for screening a material for treating liver disease, and a composition for treating or preventing liver disease comprising a material inhibiting TM4SF5 protein expression or the expressions and phosphorylations of TM4SF5 expression related signaling proteins.

Composition for diagnosing, treating, and preventing liver disease

Disclosed relates to a novel chalcone derivative, pharmaceutically acceptable salt thereof, a method for preparing the same and uses thereof, the chalcone derivative being readily obtained through the steps of: reacting aminoacetophenone with sulfonylchloride under the presence of an appropriate salt; and reacting the compound prepared in the above step with hydroxybenzaldehide under the presence of an appropriate catalyst. The chalcone derivative of formula 1 in accordance with the present invention having strong enzyme inhibitory activities for glycosidase can be effectively used in preventing and treating various diseases induced by glycosidase, and the chalcone derivative of the invention having tyrosinase and melanin synthesis inhibitory activities can be effectively used as a skin-whitening compound.

Chalcone derivatives, pharmaceutically acceptable salt, method for preparation and uses thereof

Growing community of inventors

Gyeongsangnam-do, South Korea

Ki Hun Park