Korea Research Institute of Bioscience and Biotechnology

Dongguk University Industry-academic Cooperation Foundation

Ki Hoon Lee

Hwan Mook Kim

Chang Woo Lee

Song Kyu Park

Bum Woo Park

Gyoon Hee Han

Hee Yoon Lee

Tae Gyu Chun

Dong Kyu Ryu

Jin Ha Lee

Sang Bae Han

Yung Hee Kho

Sun Young Kim

Kyeong Seok Lee

Seung-Hee Lee

Ji Duck Kim

Jung Joon Lee

Mi Sun Won

Jeom Yong Kim

Kyung Sook Chung

Kiho Lee

Ho Jae Lee

Jin Hyuk Yang

Bong Yong Lee

Hyang Woo Lee

Jeung Whan Han

Yong Kee Kim

Kyunga Yu

Hyo Kon Chun

Yinglan Jin

Bum Woo; Park

The present invention relates to a compound inhibiting HF-1 activity, a preparation method of the same, and a pharmaceutical composition comprising the same as an active ingredient. The compound of the present invention demonstrates anticancer activity not by non-selective cytotoxicity but by inhibiting the activity of HIF-1, the transcription factor playing an important role in cancer cell growth and metastasis. Accordingly, the compound or the pharmaceutically acceptable salt thereof according to the present invention inhibits HIF-1 activity, and therefore can be used as a therapeutic agent for solid tumors such as colon cancer, liver cancer, stomach cancer and breast cancer. In addition, the compound or the pharmaceutically acceptable salt thereof according to the present invention can be used as an active ingredient for a therapeutic agent for diabetic retinopathy or arthritis which may become worse when hypoxia-induced VEGF expression by HIF-1 increases.

Aryloxy phenoxy acrylic compound having HIF-1 inhibition activity, method for preparing same, and pharmaceutical composition containing same as an active ingredient

The present invention is related to new 2-oxo-cyclic compound the process for preparing them and a pharmaceutical composition comprising the same. The present invention provides a pharmaceutical composition for preventing and treating the inflammatory disease comprising the pain or inflammation caused by rheumatic disease, for example, rheumatoid arthritis, spondyloarthopathies, gout, osteoarthritis, systemic lupus erythematosus and juvenile arthritis, and inflammatory syndrome for example, from myositis, gingivitis, synovitis, ankylosing spondylitis, burstitis, burns and scar, inflammatory Crohn's disease, Types I diabetes. therefore, it can be used as the therapeutics for treating and preventing inflammatory diseases.

2-oxo-heterocyclic compounds and the pharmaceutical compositions comprising the same

The present invention is related to novel use of 2-oxo-heterocyclic compounds having anticancer activity and the process for preparing them and a pharmaceutical composition comprising the same. The present invention provides a pharmaceutical composition for preventing and treating the cancer disease comprising lung cancer, bone cancer, pancreatic cancer, skin cancer, cancer of the head and neck, cutaneous or intraocular melanoma, uterine cancer, ovarian cancer, rectal cancer or cancer of the anal region, stomach cancer, colon cancer, breast cancer, gynecologic tumors, Hodgkin's disease, cancer of the esophagus, cancer of the small intestine, cancer of the endocrine system, sarcomas of soft tissues, cancer of the urethra, cancer of the penis, prostate cancer, chronic or acute leukemia, solid tumors of childhood, lymphocytic lymphonas, cancer of the bladder, cancer of the kidney or ureter, or neoplasms of the central nervous system, therefore, it can be used as the therapeutics for treating and preventing cancer diseases.

2-oxo-heterocyclic compounds and pharmaceutical compositions

Growing community of inventors

Daejeon, South Korea

Ki Hoon Lee