Ajou University Industry-Academic Cooperation Foundation

Samsung Electronics Co., Ltd.

Korea Institute of Science and Technology

Inje University Industry-Academic Cooperation Foundation

Ki-Dong Park

Kyung-Min Park

Soo-Hyun Kim

Young-ha Kim

Yoon-Ki Joung

Young-Min Kim

Ki-Sung Kim

Soo-Hong Lee

Young-Il Yang

Sung-Won Choi

Won-Jin Lee

Sang-Joong Park

Sung-Ki Seo

Sang-Cheul Lee

Hyoung-Bin Lee

Ho-Keun Oh

Yun-Ki Lee

Min-Young Choi

Won-Kyu Lee

Dong-Jun Ahn

Il-Keun Kwon

Eu-Gene Lih

Disclosed are a multilayered cell sheet of cardiac stem cells (CSCs) and a method of manufacturing the same. In particular, the present disclosure provides a method of manufacturing a multilayered cell sheet according to a single step culture procedure by using, as a three-dimensional matrix, a biodegradable natural polymer hydrogel and embedding CSCs in the hydrogel. The multilayered cell sheet of the present disclosure does not require any special device for the manufacturing, is manageable with good physicomechanical property, increases a cell engraftment rate after transplantation based on sufficient accumulation of various growth and protective factors and extracellular matrix between cells, and is also self-assembled by the cell-mediated hydrogel compaction, making nutrients transfer easy. Therefore, the multilayered cell sheet of the CSCs is expected to be usefully applicable as a therapeutic agent for myocardium regeneration.

Multilayered cell sheet of cardiac stem cells and method of preparing the same

Disclosed herein are an in situ-forming, bioadhesive hydrogel and the medical uses thereof. Being formed by in situ crosslinking through an enzymatic reaction, the hydrogel has an advantage over conventional bioadhesive hydrogels in terms of biocompatibility. In addition, the in situ-forming bioadhesive hydrogel has excellent biocompatibility and mechanical strength and has excellent tissue adhesiveness thanks to modification with/without dopa derivatives. The hydrogel finds a variety of applications in the biomedical field, including bioadhesives or hemostats, implant substances for tissue regeneration and augmentation, carriers for delivering biologically active materials or drugs, etc.

In situ-forming hydrogel for tissue adhesives and biomedical use thereof

Disclosed are in situ-forming injectable hydrogel and medical uses thereof. In the in situ-forming injectable hydrogel two or more homogeneous or heterogeneous polymers are bonded to each other by a dehydrogenation reaction between phenol or aniline moieties on adjacent polymers, wherein a polymer backbone is grafted with a phenol or aniline moiety using a linker. In contrast to conventional hydrogel, the in situ-forming injectable hydrogel is superior in terms of in vivo stability and mechanical strength thanks to the introduction of a water-soluble polymer as a linker which leads to an improvement in the reactivity of phenol or aniline moieties. Having the advantage of superior bio stability and mechanical strength, the hydrogel finds a variety of applications in the biomedical field.

In situ forming hydrogel and biomedical use thereof

A user input method and device of a mobile communication terminal that includes displaying a menu screen comprising images associated with each key function and menu function necessary for terminal control, depending on a currently set operation mode; detecting a preset indicator from a video that is photographed by camera when augmented reality input mode is set, real-time synthesizing the detected indicator with the menu screen, and displaying the synthesized screen; and in a state where a predetermined one of the images and the indicator are overlapped on the synthesized screen, upon detection of a preset user motion associated with selection from the video photographed by the camera, performing an operation based on the function associated with the image.

User input method and device of mobile communication terminal

Disclosed is a biocompatible medical material and porous scaffold for use in tissue engineering, made from a biodegradable glycolide/&#x3b5;-caprolactone copolymer having a repeat unit ofwherein x and y are integers greater than or equal to 18, the copolymer has an average molecular weight of about 10,000 daltons or more, and the molar ratio of glycolide: &#x3b5;-caprolactone in the copolymer is about 4.0:6.0 to 6.0:4.0.

Medical materials and porous scaffolds for tissue engineering made from the biodegradable glycolide/&#x3b5;-caprolactone copolymer

A surface-modified medical metallic material, which comprise a metallic substrate; a thin film of gold or silver coated on the surface of said substrate; a functional sulfur compound adsorbed on said thin film; and a sulfonated poly(ethylene oxide) (PEO) derivative chemically bonded to functional groups of said sulfur compound, and a method for the preparation thereof are disclosed. It is also disclosed a stent, a cardiac valve and a catheter prepared from the surface-modified metal material.

Biocompatible metallic materials grafted with sulfonated poly(ethylene oxide) and preparation thereof

A terminal connecting device includes a main body of a terminal block having diaphragms and supporting strips, a terminal plate positioned at the top of the supporting strips, movable terminals supported by a spring to attach or detach lead wire positioned on the terminal plate, a restraining structure, proximate to the movable terminals, which limits the movement of the lead wire, and a terminal screw coupled with the movable terminals after being penetrated through the through hole of the lead wire and fastened at a screw hole of the terminal plate. The restraining structure restricts the lead wire from diverting or dropping, thereby preventing safety accidents such as stopping the operation of facility or electric shock. The restraining structure also allows easy penetration of the terminal screw through the through hole of the lead wire in fixing the lead wire, thereby improving productivity due to ease of fastening the terminal screw. The restraining structure may be extending parts extending from the movable parts or hitching jugs protruding at both lateral surfaces of the main body.

Terminal connecting device having a restraining structure

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Seoul, South Korea

Ki-Dong Park