Ajou University Industry-academic Cooperation Foundation

Korea Institute of Science and Technology

Incheon University Industry Academic Cooperation Foundation

Seoul National University

Ki Dong Park

Kyung Min Park

Young Ha Kim

Soo Hyun Kim

Dong Keun Han

Jong Hoon Choi

Soo-Hong Lee

Eugene Lih

Hyun Chul Goo

Won Kyu Lee

Su Jin Park

Hack Joo Kim

Jin Woo Bae

Yun Ki Lee

Yunki Lee

Bae Young Kim

Thi Phuong Le

Thi Thai Thanh Hoang

Si Min Lee

A preparation method of calcium peroxide-mediated in situ crosslinkable hydrogel as a sustained oxygen-generating matrix, includes: a) reacting a natural or a synthetic polymer with Traut's reagent (TR) in a solvent, and synthesizing a polymer derivative having thiol group in backbone of the polymer derivative; and b) mixing and reacting a solution of the polymer derivative having thiol group with calcium peroxide (CaO), and thereby forming a hydrogel, wherein in the step b), disulfide bonds (&#x2014;S&#x2014;S) are induced between backbones of the polymer derivative having thiol group attached by decomposition of calcium peroxide (CaO), and thereby in situ crosslinking is formed.

Preparation method of calcium peroxide-mediated in situ crosslinkable hydrogel as a sustained oxygen-generating matrix, and biomedical use thereof

Provided are an injectable tissue adhesive hydrogel including gamma-cyclodextrin (&#x3b3;-CD). When such an injectable tissue adhesive hydrogel including the &#x3b3;-CD is used as a skin glue, based on a fact that the &#x3b3;-CD has a bigger hydrophobic cavity than that of &#x3b1;- and &#x3b2;-CDs, the injectable tissue adhesive hydrogel including the &#x3b3;-CD has stronger interactions than host-guest interactions. In addition, hydrogen bonding in the injectable tissue adhesive hydrogel including the &#x3b3;-CD can improve both cohesiveness and adhesiveness of gelatin. The injectable tissue adhesive hydrogel including the &#x3b3;-CD having excellent cell viability is used for adhesion of a skin incision, to thereby effectively promote tissue regeneration.

Injectable tissue adhesive hydrogel including gamma-cyclodextrin and biomedical use thereof

The present invention relates to a method for preparing a hydrogel, including the steps of: preparing an enzyme-immobilized support; making contacting with a polymer having a phenol or aniline functional group at a side change and the support in the presence of hydrogen peroxide to cross-link the same; and obtaining a hydrogel by separating the enzyme-immobilized support. According to the present invention, a hydrogel is formed by cross-linking a polymer having a phenol or aniline functional group at a side chain through an enzyme-immobilized support, and thus a hydrogel containing no enzymes is obtained. Therefore, the biomedical application range of a hydrogel can be expanded since it is possible to overcome an in vivo safety problem such as immune reaction caused by an enzyme.

Method for preparing in situ-formed hydrogel using enzyme-immobilized support, and biomedical use thereof

Disclosed is a multi-layered structure for drug reservoir, comprising a first micelle layer for crosslinking and adhesion, comprising a drug, a multi-arm polymer, a phenol derivative, and a dopa derivative and having a one or two-layered structure; a second micelle layer for crosslinking, being stacked on the first micelle layer, comprising a drug, a multi-arm polymer, and a phenol derivative, and having a one or two-layered structure; and a physiologically active material layer, being stacked on the second micelle layer, comprising a physiologically active material, a water-soluble polymer, and a phenol derivative, and having a one or two-layered structure.

Multi-layered structure for drug reservoir and drug eluting stent including the same

Disclosed are surface-modified medical metallic materials and preparation thereof. The medical metallic material is prepared by coating a gold or silver thin layer onto a base metal, adsorbing a polyfunctional sulfur compound onto the gold or silver thin layer, and chemically bonding a biologically active material such as heparin or estradiol to the functional group of the sulfur compound. The biologically active material is firmly bonded to the base metal via the sulfur compound. Being significantly improved in antithrombogenicity and biocompatibility, the metallic materials are suitable for use in various implants, including stents, artificial cardiac valves and catheters.

Biocompatible metallic materials grafted with biologically active compounds and preparation thereof

The present invention relates to polyethyleneglycol/polylactide(or polyglycolide or polycaprolactone)/polyethyleneglycol triblock copolymers with an enhanced reactivity, and process for their preparation. More specifically, the present invention is directed to triblock copolymers that are obtained by the process comprising the step of synthesizing a polylactide(or polyglycolide or polycaprolactone) having hydroxy groups at both ends and the step of coupling said polylactide with polyethyleneglycol having an acylhalide group of a high reactivity at one of its ends, and the process for preparing the same Since the triblock copolymer according to the present invention has an ester structure with good biocompatibility, it can be applied extensively for biomaterials used in tissue engineering, in a matrix that slowly releases drugs, etc.

Biodegradable triblock copolymers and process for their preparation

The specification describes an invention of calcification resistant bioprosthetic heart valves which can be used for a long term, and have good blood compatibility and in vivo stability, and have high calcification resistance. The bioprosthetic heart valves of the invention can be prepared by binding sulfonated polyethylene oxide (PEO) derivatives covalently to the tissue. The valves have an anionic effect equal to that of chondroitin sulfate, space filling effect, and blocking effect of the carboxyl group of collagen which has been known as one factor of the calcium deposition,. In particular, the present method has better advantages in view of calcification resistance than any other conventional methods, because it suppresses thrombosis and embolism and decreases incidence of infection.

Bioprosthetic heart valves having high calcification resistance

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Seoul, South Korea

Ki Dong Park