Yamanouchi Pharmaceutical Company Ltd.

Khozi Nakano

Masuo Murakami

Yukiyasu Murakami

Isao Souzu

Ichiro Isaka

Akio Koda

Teruaki Ozasa

Teruya Kashiwagi

The penicillin derivatives represented by the formula ##SPC1## Wherein ring A represents a 5- or 6-membered single or fused ring which may contain one or more nitrogen atoms, an oxygen atom, or a sulfur atom; R.sup.1, R.sup.2, and R.sup.3, which may be the same or different, each represents a hydrogen atom, a hydroxy group, a lower alkyl group, a nitro group, a halogen atom, or an oxo group; and B represents a p-hydroxyphenyl group or a 1,4-cyclohexadien -1-yl group, and their nontoxic pharmaceutically acceptable salts. The compounds are antibiotics having excellent antibacterial activity in particular with respect to the Pseudomonas genus.

Penicillin derivatives

Growing community of inventors

Shiraoka, Japan

Khozi Nakano