Other

Fujifilm Corporation

University of California

Khanitha Pudhom

Kozo Sato

Hiroshi Kitaguchi

Masayuki Kawakami

James H McKerrow

Masataka Ihara

Kiyosei Takasu

Gabriel Navarro

Roger G Linington

Roger R Linington

Small molecule therapeutics for the treatment of parasitic diseases, in particular, semi-synthetic derivatives of the fungally-derived natural product merulin A for the treatment of African Sleeping Sickness.

Methods for making and using novel semi-synthetic small molecules for the treatment parasitic disease

Small molecule therapeutics for the treatment of parasitic diseases, in particular, semi-synthetic derivatives of the fugally-derived natural product merulin A for the treatment of African Sleeping Sickness.

Semi-synthetic small molecules for the treatment parasitic disease

The present invention is to provide a medicinal composition for preventing or treating parasitic protozoan infections, having a high selective toxicity against parasitic protozoan infection, and a superior preventive or treating effect. A medicinal composition for preventing or treating parasitic protozoan infections comprises a compound shown by the following general formula (1) as an active ingredient (wherein R represents an alkyl group, aryl group or heterocyclic group; A and B each independently represents a 5- or 6-membered ring containing at least one hetero atom, or a condensation ring wherein 1 or more 3- to 8-membered ring is condensed thereto; Y represents S, O, Se, or &#x2014;NR&#x2014; (Rrepresents an alkyl group, aryl group or heterocyclic group); L, L, L, Land Leach independently represents a methine group; Q represents a physiologically acceptable anion; k represents an integer of 0 to 2, necessary to make the electric charge of the whole molecule 0; p and q each represents an integer of 0 to 3, wherein the sum of p and q is 1 or more, and 6 or less).

Medicinal composition for prevention or treatment of parasitic protozoan infection

The present invention is to provide an anti-trypanosomiasis agent having a high selective toxicity, and high preventing or treating effect against trypanosomiasis, comprising a compound shown by the following general formula (1) as an active ingredient (wherein Rand Reach independently represents a hydrogen atom, halogen atom, hydroxyl group, oxygen atom, Calkyl group, Calkoxy group, Caryl group, Caryloxy group, Calkoxycarbonyl group or Calkylaminocarbonyl group, and may be bound to each other; R, R, and Reach independently represents a Calkyl group or Caryl group; Rand Reach independently represents a hydrogen atom, halogen atom, hydroxyl group, oxygen atom, Calkyl group, Calkoxy group, Caryl group, Caryloxy group, or Calkoxycarbonyl group, and may be bound to each other; Y and Z each independently represents an atom group necessary to form a 5- or 6-membered heterocycle; m and n each represent 0 or 1; Q represents a physiologically acceptable anion; k represents an integer of 0 to 2, necessary to make the electric charge of the whole molecule 0).

Anti-trypanosomiasis agent

Growing community of inventors

Bangkok, Thailand

Khanitha Pudhom