Reliance Life Sciences Pvt. Ltd.

Reliance Life Science Pvt. Ltd.

Khan Firdos Alam

Geeta Ravindran

Satish Mahadeorao Totey

Pai Rajarshi

Khanna Aparna

Tipnis Shabri

Subhadra Devi Kashyap

Totey Satish Mahadeorao

The present disclosure describes mammalian pluripotent embryonic-like stem cells (ELSCs) isolated from corneal limbal tissue, a non-embryonic tissue. The ELSCs of the present disclosure are capable of proliferating in an in vitro culture, maintain the potential to differentiate into cells of endoderm, mesoderm, and ectoderm lineage in culture, and are capable of forming embryoid-like bodies when placed in suspension culture. Thus, these cells possess multi-lineage differentiation potential and self-renewing capability. ELSCs may be a promising therapeutic tool, and may provide new therapeutic alternatives for various diseases, conditions, and injuries.

Pluripotent embryonic-like stem cells derived from corneal limbus, methods of isolation and uses thereof

The present disclosure is directed to improved methods for efficiently producing neuroprogenitor cells and differentiated neural cells such as GABAergic neurons from pluripotent stem cells, for example embryonic stem cells. Using the disclosed methods, cell populations containing a high proportion of GABAergic neurons have been isolated. The neuroprogenitor cells and terminally differentiated cells of the present disclosure can be generated in large quantities, and therefore may serve as an excellent source for cell replacement therapy in neurodegenerative disorders and neuronal diseases such as stroke, ischemia, epilepsy, and Huntington's disease.

In vitro generation of GABAergic neurons from pluripotent stem cells

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Navi, India

Khan Firdos Alam