Koninklijke Philips Corporation N.v.

Khalid Shahzad

Ladislav Jankovic

Jeffrey Arthur Shimizu

Raymond C Chan

Sheng-Wen Huang

Ramon Quido Erkamp

Robert Manzke

Emil George Radulescu

Daniel Robert Elgort

John Domm

Yan Shi

Duncan J Anderson

Functional imaging for localization in biological tissue entails measuring a response in the tissue () to electromagnetic radiation. A catheter () for real-time monitoring of cardiac ablation is employed to distinguish a hemorrhage zone () from the sandwiching necrotic and healthy tissue, or to distinguish exogenous photoacoustic contrast agent from bordering native tissue. A pair of wavelengths is selected for differential absorption () of the radiation in, correspondingly, the hemorrhage zone or where the contrast agent exists, and relatively similar absorption elsewhere. Near infrared laser or LED light may be used photoacoustically to serially acquire (S, S) the two datasets to be compared, each representative of a time waveform. Alternatively, acquisition is for a pair of wavelength bands of microwave-induced thermoacoustic data. In either case, the members of the dataset pair are combined () by subtraction or division to effect the piece-wise cancellation/enhancement for display () of the resulting signal in real time.

Photoacoustic catheter for functional-imaging-based ablation monitoring

Apparatus, systems and methods are provided for production and integration of compact illumination schemes. More particularly, disclosed embodiments relate to apparatus/systems and methods for production of highly compact illumination schemes, whereby photoacoustic waves are induced in a target sample. Additionally, the disclosed apparatus/systems and methods are effective to produce compact and portable integrated transducer-illumination arrays. Apparatus disclosed generally include at least one lighting source and a beamsplitting assembly. Systems disclosed generally include one or more apparatus for the production of compact lighting schemes, an ultrasonic transducer assembly and means for coupling the one or more apparatus and US transducer assembly with a target sample.

Apparatus, systems and methods for production and integration of compact illumination schemes

A tissue ablation device employs one or more energy emitters () and one or more photoacoustic sensors () in a cooperative arrangement for applying a tissue ablation therapy to a tissue (). In operation, the energy emitters () emit a tissue ablation beam (TA) into a target portion of the tissue () to form a lesion () therein, and alternatively or concurrently emit a photoexcitation beam (PE) into the target portion of the tissue () to excite a photoacoustic response from the tissue (). The photoacoustic sensor(s) () sense the photoacoustic response of the tissue ().

Tissue ablation device with photoacoustic lesion formation feedback

An apparatus for improved contrast in projection optical systems consists of a polarizing beam splitter (PBS) in combination with two or more waveplates whose fast exes are aligned perpendicular to each other. The apparatus has an effective broadband frequency response that is better than that of the individual retarders acting alone, and through the selection of a birefringence factor and thickness of the individual retarders, wavelength dependencies are minimized.

Achromatic apparatus for producing a wavelength-independent high contrast light signal

An image display system utilizes primarily non-absorptive polarization components to polarize light illuminating an imaging device. The non-absorptive polarization components reduce cost and cooling requirements, increase durability, and permit the use of high powered light sources.

Image display system

An optical illumination apparatus includes an illumination source, a pair of spaced integrator plates each having a plurality of lenslets, a conduit array, having a respective aperture corresponding to a plurality of the lenslets disposed there between, with non-reflective optically absorptive walls, and a relay optical structure for integrating light emitted from said second array of lenslets on a focal plane. The apparatus is employed by illuminating a first integrator plate having lenslets, subject to spatial intensity variations, segregating light from each respective lenslet with an elongated baffle, having a respective aperture for each of a plurality of respective lenslets, capturing light from each aperture with a second integrator plate having lenslets, and relaying the light to a focal plane, whereby light rays impinging on the walls of the elongated baffle are not transmitted through the aperture, thus substantially attenuating light rays having acute angles, to uniformly illuminate the focal plane.

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Shrub Oak, NY, United States of America

Khalid Shahzad