Other

Khalid Mohammed Khan

Atta-Ur Rahman

Muhammad Iqbal Choudhary

Atia-Tul Wahab

Humera Jahan

Usman Ashfaq

Javed Akram

Zulfiqar Ali Khan

Abdul Hameed

M Iqbal Choudhary

Sheikh Riazuddin

Saba Farooq

Rima D Alharthy

Nafees Iqbal

Syed Abid Ali

Syed Tarique Moin

Iqbal Choudhary

Ajmal Khan

Tayyab Husnain

Mehwish Manzoor

Nida Ambreen

Farzana Naz

Zarbad Shah

M Kamran Azim

Jamshed Hashim

Yasmeen Rashid

Shakeel Ahmad

Osman Ali

Shaheen N Khan

Usman Zafar

Shahnaz Perveen

Fatima Zahra Basha

Shaikh Riazuddin

Mariya al-Rashida

Atta-ur Rehman

The current study established that treatment of diabetes using compound 1(2,4-dinitroanilino-benzoic acid), an anthranilic acid derivative, by restoring the functional activities of the pancreas via its insulinotropic action.

2, 4-dinitroanilino-benzoic acid: novel insulinotropic agent for the treatment of diabetes

The current invention relates to ionic liquid preparation and their application in organic synthesis. More specifically, the present invention relates to the quinoline based ionic liquids having fluoride counter anion and their applications in click chemistry, Knoevenagel condensation to 1,2,5,6-tetrahydronicotinonitrile (12), and pyrazol (15) formation.

Process for the preparation of quinoline based ionic fluoride salts (QUFS)

One embodiment of the invention relates to treating diseases associated with increased urease enzyme activity comprising administering an effective amount of a compound selected from a group consisting of 28 thiazoles Schiff bases. Kinetic studies were performed on ten (10) of the most active compounds.

Schiff bases of thiazoles: a new class of ureases inhibitors

The invention relates to methods of inhibiting the protein glycation process and the associated formation of Advanced Glycation End products (AGEs) in hyperglycemia by administering 6-Nitrobenzimidazole derivatives. These derivatives were found to be effective not merely against the formation of AGE, but they can inhibit the action of AGEs at post-receptor levels.

Inhibitors of advanced glycation end-products (ages)formation

Two thiourea derivatives N-(3-chlorophenyl)-N'-(3,4-difluorophenyl)thiourea and N-(3-chlorophenyl)-N-(3-methoxyphenyl)-thiourea are reported as treatment of multidrug resistance infections from

Thiourea derivatives

HslVU is the proteasome-related system composed of HslV peptidase and HslU chaperone. It is involved in intracellular proteolysis. The presence of HslVU homologs in pathogenic microbes and its absence in human makes it an antimicrobial drug target. The functional HslVU complex forms when HslV dodecamer is flanked at both ends by HslU hexamers. In the HslVU complex, intercalation of C-termini residues of HslU subunits into the clefts between adjacent HslV subunits results in allosteric activation of HslV. We identified small molecules capable of activating HslV peptidase in the absence of its natural activator HslU. Quinazoline and chromone derivatives were suggested by ligand docking to bind at the HslU C-termini intercalation pockets in the HslV. This was confirmed by HslV activation assays with these compounds that gave EDin sub-micromolar range. The results showed that small, extracellular non-peptidic molecules can activate the HslV peptidase which in turn would initiate intracellular proteolysis.

Small molecule activators of HsIV protease for development of novel antimicrobials

Surprising antiviral activity of 3-amino-2-(4-nitrophenyl)-4-(3H)-quinazolinone (Compound 1) was reported in the treatment or prevention of viral infections, particularly in combination with other antiviral agents such as interferon and/or ribavarin.

3-amino-2-(4-nitrophenyl)-4-(3H)-quinazolinone or derivatives thereof for treating or preventing antiviral infections

Surprising antiviral activity of 7-Nitro-2-(3-nitro phenyl)-4H-3,1-benzoxazin-4-one (Compound 1) was reported in the treatment or prevention of viral infections, particularly in combination with other antiviral agents such as interferon and/or ribavarin.

7-nitro-2-(3-nitro phenyl)-4H-3,1-benzoxazin-4-one or derivatives thereof for treating or preventing antiviral infections

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Karachi, Pakistan

Khalid Mohammed Khan