The United States of America, As Represented by the Secretary, Department of Health and Human Services

Khalid Chakir

Irving William Wainer

Weizhong Zhu

Darrell R Abernethy

Rui-Ping Xiao

Farideh M Beigi Abhari

Rui Ping Xiao

Farideh M Beigi

This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogues which are highly effective at binding &#x3b2;2-adrenergic receptors. Exemplary chemical structures for these analogues are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogues, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease.

Preparation of (R,R)-fenoterol and (R,R)- or (R,S)-fenoterol analogues and their use in treating congestive heart failure

This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogs which are highly effective at binding &#x3b2;2-adrenergic receptors. Exemplary chemical structures for these analogs are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogs, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease.

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Khalid Chakir