Essentialis, Inc.

Dade Behring Inc.

Khaled A Yamout

Neil Madison Cowen

Mae W Hu

Yi Feng Zheng

Hshiou-ting Liu

Donald E Berger, Jr

Kenneth B Kashkin

Neil M Cowen

Provided are immediate or prolonged administration of certain salts of Kchannel openers such as diazoxide to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving Kchannels. Also provided are pharmaceutical formulations, methods of administration and dosing of the salts that achieve these outcomes and reduce the incidence of adverse effects in treated individuals. Further provided are method of co-administering the salts with other drugs to treat diseases of humans and animals.

Salts of potassium ATP channel openers and uses thereof

Methods, compositions and kits are disclosed. Enzyme conjugates of Formula I may be employed in assays for the determination of an amphetamine and/or a methamphetamine. Immunogenic conjugates of Formula I may be employed to prepare antibodies for an amphetamine and/or for a methamphetamine for use in assays for the determination of an amphetamine and/or a methamphetamine. The enzyme conjugates may also be employed to screen antibodies for use in such methods.

Assays for amphetamine and methamphetamine using stereospecific reagents

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Carlsbad, CA, United States of America

Khaled A Yamout