Cytiva Sweden Ab

Key Hyckenberg

Kjell Karlsson

Lars Mattsson

Orjan Grelsson

Johan Arthursson

Lotta Hedkvist

Petra Bangtsson

Jens Widehammar

Stefan Willehadson

Roger Lundqvist

Gunnar Malmquist

Mikael Berg

Helena Skoglar

Par Haggblad

Dan Andersson

Örjan Grelsson

Sara Sendabo

Linda Mathiasson

Mikael Carlsten

Henrik Lundkvist

Christoffer Hultqvist

Magnus Karlsson

Niklas Engblom

Ulrika Skarp

Mikael Johan Helmer Eugen Berg

Lars Henning Ivar Mattsson

Orjan Bo Grelsson

The present invention relates to a method for optimizing a bioprocess purification system comprising a bioreactor configured to provide a harvest comprising a target composition, and a purification process arranged downstream the bioreactor and being configured for purification of the harvest to produce a target product having a desired characteristics. The method comprising: a) detecting () at least one quality attribute indicative of characteristics of the target product in a downstream process, b) identifying () correlations between the at least one quality attribute measured in the downstream process and parameters to control a cell culture process in the bioreactor, and c) controlling () the cell culture process to meet the desired characteristics based on the identified correlations, whereby the target characteristics is within a p re-determined range.

Method in bioprocess purification system

The present disclosure relates to a method and system for monitoring a bio-pharmaceutical process, said bio-pharmaceutical process being controlled based on as set of instructions for controlling said biopharmaceutical process. The method comprises the following steps performed by a bio-pharmaceutical process monitoring element: obtaining (S) said set of instructions for controlling the biopharmaceutical process, and while the instructions of the set of instructions for controlling the bio-pharmaceutical process are executed, for each executed instruction receiving (S) an execution status update indicating which instruction is presently executed or has just been finished, and forming (S) an execution status indication relating the instruction presently executed or just finished to its position in the set of instructions based on the received execution status update.

Method and system for monitoring a bio-pharmaceutical process

A method of automated configuration in a bioprocess system and to verify a process defined by a flow path representation. The method comprises the steps of: capturing one image of the bioprocess system comprising tubing for the fluid communication between units of the bioprocess system; analyzing the captured image to identify the tubing connecting units of the bioprocess system; producing a processed representation from the captured image wherein at least a part of the tubing is identified; and comparing the processed representation with the flow path representation to verify their functional concordance.

Bioprocess system and method providing automated configuration detection

A chromatography system arranged to perform automated chromatography column efficiency testing for a specific column to determine efficiency parameters and to further provide guidance to the user. The system has a controller arranged to automatically access data to enable the calculation of a column compression plate height, said data being derived from at least stored parameters of the specific column and the resin to be used in the column, to calculate the efficiency of the column.

Chromatography system

The present invention relates to a liquid chromatography system configured to operate with at least one column and configured for purification of a sample comprising a target product using a predefined process. The liquid chromatography system comprises a controller configured to: control the operation of the chromatography system to run the predefined process; retrieve column data accessible from a data storage, the column data being specific to each column; and adapt at least one process parameter of the predefined process for each column based on column data. Whereby the predefined process is adapted to each column to obtain the target product and maintain the performance of the liquid chromatography system.

Apparatus, method, and computer program product for adapting a predefined liquid chromatography process

A method, system, gateway and computer program for remote controlling and monitoring of at least one instrument, for example a bioproces sing instrument. The system can comprise: at least one instrument to be controlled and/or monitored; at least one instrument server connected to the at least one instrument, said instrument server comprising an instrument control software; at least one gateway connected to the at least one instrument server; a transferring means provided in the at least one instrument server, said transferring means being arranged to receive information from the at least one connected instrument and forward said information to the at least one gateway.

Method and system for monitoring and controlling instruments

Disclosed is a system for remote controlling and monitoring of at least one instrument, for example a bioprocessing instrument, said system comprising: at least one instrument to be controlled and/or monitored; at least one instrument server connected to the at least one instrument, said instrument server comprising an instrument control software; at least one gateway connected to the at least one instrument server; a transferring means provided in the at least one instrument server, said transferring means being arranged to receive information from the at least one connected instrument and forward said information to the at least one gateway; a first self-hosted web server containing a web application provided in the at least one instrument server for providing possibility to control the at least one instrument via a web browser in an instrument control web page; a publishing means provided in the at least one gateway, said publishing means being arranged to receive information from at least one instrument server and publish said information in an instrument monitoring web page; a second self-hosted web server containing a web application provided in the at least one gateway for providing possibility to monitor the at least one instrument in the instrument monitoring web page via a web browser.

The present invention relates to a liquid chromatography system () configured to operate with at least one column and configured for purification of a sample comprising a target product using a predefined process. The liquid chromatography system comprises a controller () configured to: control the operation of the chromatography system to run the predefined process; retrieve column data accessible from a data storage, the column data being specific to each column; and adapt at least one process parameter of the predefined process for each column based on column data. Whereby the predefined process is adapted to each column to obtain the target product and maintain the performance of the liquid chromatography system.

The present invention relates to a method of automated configuration in a bioprocess system () and to verify a process defined by a flow path representation. The method comprises the steps of: &#x2014;capturing one image of the bioprocess system () comprising tubing () for the fluid communication between units of the bioprocess system (); &#x2014;analyzing the captured image to identify the tubing () connecting units of the bioprocess system (); &#x2014;producing a processed representation from the captured image wherein at least a part of the tubing () is identified; and &#x2014;comparing the processed representation with the flow path representation to verify their functional concordance.

Disclosed is a method for automatic installation and setting up of an instrument (), comprising the steps of: connecting (S) the instrument () to a service software system () in a network () via a first communication interface (); sending (S) identification information () of the instrument () from the instrument to the service software system () via the first communication interface (); recognizing (S) in the service software system () at least one characteristic of the instrument () by analyzing the identification information (); based on said at least one characteristic or identification information, creating (S) by the service software system () dedicated high level control software () comprising parts of the control software needed for the instrument; based on said at least one characteristic or identification information, sending (S) to the instrument () from the service software system () software to enable a second communication interface (), and low level control software components needed for local control of the instrument, installing (S) and configuring in the instrument the low level control software components received from the service software system; starting (S) a built-in control software () in the instrument; using the (S) the built-in control software in the instrument to access the high level control software dedicated for the instrument via the first, or a second communication interface (), said built-in control software using the low level control software to monitor and control the instrument.

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Uppsala, Sweden

Key Hyckenberg