Tianjin Sunrise Technologies Development Co., Ltd.

Tianjin Sunshine Optics Technologies Co., Ltd.

Tianjin University

Kexin Xu

Jin Liu

Renda Wang

Yiwen Ma

Wenliang Chen

Yuxiang Wang

Wanjie Zhang

Tongshuai Han

Jun He

Guang Han

Dachao Li

Picheng Zhao

Zhenhui Du

A non-invasive detection method, device, system and wearable apparatus for tissue element are provided. The method includes: emitting incident light of multiple predetermined wavelengths to a detected site, respectively; for each predetermined wavelength, obtaining light intensity values emitted from a surface of the detected site based on multiple photosensitive surfaces, wherein multiple photosensitive surfaces are at predetermined distances from a center of the incident light; and determining a concentration of the tissue element to be detected according to light intensity values in multiple predetermined wavelengths.

Non-invasive detection method, device, system and wearable apparatus for tissue element

The present disclosure provides a method for correcting a light intensity measurement value is provided. The method includes: emitting detection light into a measured object; measuring a light intensity measurement value at a measurement position, and measuring light intensity of photons at a benchmark position as a light intensity reference value. A sensitivity of the light intensity of photons to a concentration change of a specific substance in the measured object is less than or equal to a preset threshold, and a change rate of the light intensity at the measurement position with a concentration of the specific substance in the measured object is greater than a change rate of the light intensity at the benchmark position with the concentration of the specific substance; correcting the light intensity measurement value by using the light intensity reference value. The present disclosure further provides a concentration measurement device.

Method for correcting light intensity measurement value and concentration measurement device in which reference value is measured at time gate fixed optical length

A method of processing spectral data is disclosed and may include the steps of illuminating a medium to detect an inside particular component with light; obtaining a first spectral data for the medium at a first radial position and a second spectral data for the medium at a second radial position, wherein the first radial position and the second radial position are selected arbitrarily; and performing differential processing on the first spectral data and the second spectral data.

Processing, model establishment, and predication methods of multi-position diffuse spectral data and processing apparatus

A method of processing diffuse spectrum data may include: obtaining diffuse spectrum data of a medium to be detected at one or more first radial positions; and determining optical information caused by substantially only a variation in scattering characteristic of the medium to be detected and/or optical information caused by substantially only a variation in absorption characteristic of the medium to be detected at one or more second radial positions from the obtained diffuse spectrum data.

Absorption and scattering effects separation from diffuse spectrum data and model establishment and concentration prediction based thereon

A method of detecting a concentration of a target component by using a reference wavelength includes: defining a wavelength at which a light intensity is insensitive to the variation of the target component concentration as a reference wavelength for the target component; detecting spectra at both the reference wavelength and a further measuring wavelength; processing the spectrum detected at the further measuring wavelength, with the spectrum detected at the reference wavelength as an inner reference, to obtain a characteristic spectrum including specific information of the target component; building a calibration model between the characteristic spectrum and the concentration of the target component; and determining the concentration of the target component based on the calibration model.

Method of component concentration detection based on reference wavelength

Disclosed is a sensor for measuring the amount of an analyte to be detected in human interstitial fluid, comprising a micro-cantilever sensing unit which includes: a first substrate; a micro-cantilever which is substantially in parallel with the first substrate and one end of which is supported onto the first substrate; a gold film formed onto at least one side of the micro-cantilever; a protein layer formed on the gold film, the protein layer being used to adsorb, at a surface thereof, the analyte to be detected in human interstitial fluid; a driving electrode provided on the first substrate; a micro-cantilever electrode which is provided on the first substrate at a position where the micro-cantilever is supported, and which is cooperated with the driving electrode so as to drive the micro-cantilever to produce resonance in a direction perpendicular to the first substrate; and a detecting electrode which is provided on the first substrate and which is cooperated with the micro-cantilever electrode so as to detect resonance frequency of the micro-cantilever. The present invention also relates to a fluid channel unit, a sensor system, and a method for measuring the amount of an analyte to be detected in human interstitial fluid.

Sensor and method for measuring amount of analyte in human interstitial fluid, fluid channel unit

A method and apparatus for noninvasive measurement of a human body component, such as glucose, in vivo, include near infrared spectroscopy based laser sources driven at a carrier frequency lying within the characteristic absorption of the component. The apparatus also drives the laser diodes with a modulation frequency to generate a frequency difference between the measuring light and reference beam, and the interference of the two beams results in a beat frequency signal, which frequency is proportional to the optical path difference between the measuring light and the reference beam. The scattering lights from human tissue with different optical lengths are simultaneously detected and selected based on the beat frequency. The method is a convenient embodiment of the floating reference principle, which takes advantage of optical length selection.

Apparatus and method for noninvasive human component measurement with selectable optical length

The present invention discloses a spectral measurement method via continuous light source and discrete light source, and a measurement instrument for non-invasive detection of human body tissue components. Said instrument includes an incident unit, a probe, a receiving unit and a data processing unit. Said composite spectral measurement method improves or strengthens the output light intensity at the wavelength that carries information of the target component within human body. It enables the spectral detection in the whole wavelength range, and thus significantly enhances the SNR of the detecting system. In the non-invasive detection instrument, light from both the continuous light source and discrete light source can be firstly selectively light-split by AOTF, or AOTF conducts light-splitting for the continuous light source, while the discrete light source LD is controlled by a spatial chopper. When data of the spectral curves achieved from said continuous light source and discrete light source are processed, data acquired under different measuring modes can be compared.

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Tianjin, China

Kexin Xu