Hoffmann-la Roche Inc.

Genentech, Inc.

Meiji Seika Pharma Co., Ltd.

Fedora Pharmaceuticals Inc.

Kewei Yang

Lionel Vedrine

Paul Spurr

Heather L Flores

Pierre Goldbach

Valérie Verhoeven

Frank Bamberg

Christelle Carl

Edward Schwarb

Elisabeth Schaible

Martin Binder

Robert Müller

Mathieu Rigollet

Baboo Dushyantsingh Goordyal

Ivy Lin

Florian Wildenhahn

A syringe () has a longitudinal body () with an interior () in which a pharmaceutical substance is arranged, a needle connected to one longitudinal end of the body () and a rigid needle shield () encasing the needle. The rigid needle shield () is essentially water vapour tight. The syringe () according to the invention allows for preventing needle clogging and, thus, proper provision of pharmaceuticals, particularly by subcutaneous, intramuscular or ocular injection.

Syringe and method of preparing syringe

The present invention relates to a pharmaceutical composition and a lyophilisate of a diazabicyclooctane derivative represented by Compound I, a process for producing the same and methods for using the same. 

Pharmaceutical forms of diazabicyclooctane derivatives and process for producing the same

The present invention relates to compounds according to Formula (II): or a stereoisomer, tautomer or pharmaceutically acceptable salt or ester thereof, wherein A, Rand Rare defined herein. Also described are pharmaceutically acceptable compositions of Formula (II) compounds as well as methods for utilizing the compounds of Formula (II) and the pharmaceutically acceptable compositions of Formula (II) compounds as antibacterial agents and &#x3b2;-lactamase inhibitors, useful in the treatment of infectious diseases.

Diazabicyclooctane compounds

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Basel, Switzerland

Kewei Yang