Endocyte, Inc.

Kevin Yu Wang

Christopher Paul Leamon

Iontcho Radoslavov Vlahov

Hari Krishna R Santhapuram

Paul Joseph Kleindl

Fei You

Le-Cun Xu

Michael Groaning

Katheryn Marie Stanford

Allen Ritter

Yingjuan June Lu

Longwu Qi

Albert E Felten

Yingcai Wang

Fei Yu

Described herein are compositions and methods for use in targeted drug delivery using cell-surface receptor binding drug delivery conjugates containing hydrophilic spacer linkers for use in treating disease states caused by pathogenic cell populations.

Conjugates containing hydrophilic spacer linkers

The present disclosure relates to pyrrolobenzodiazepine (PBD) prodrugs and conjugates thereof. The present disclosure also relates to pharmaceutical compositions of the conjugates described herein, methods of making and methods of using the same.

Conjugates for treating diseases

Described herein are compositions, methods, compounds, conjugates, and kits for use in targeted drug delivery using drug delivery conjugates containing hydrophilic spacer linkers for use in treating disease states caused by pathogenic cell populations, such as inflammatory cells.

Vitamin receptor drug delivery conjugates for treating inflammation

Processes are described for the preparation of tubulysins. The processes are useful for preparing predetermined mixtures of tubulysins, preparing single tubulysins from mixtures of tubulysins, and for converting one tubulysin into a different tubulysin. The tubulysins described herein are useful in treating diseases and disease states that include pathogenic cell populations.

Tubulysins and processes for preparing

Tubulysins are a series of naturally occurring cytotoxic agents that are of interest as anticancer therapeutic agents. Processes and intermediates useful for preparing naturally occurring and non-naturally occurring tubulysins and analogs and derivatives thereof are described.

Processes for preparing tubulysins

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Zionsville, IN, United States of America

Kevin Yu Wang