Perseptive Biosystems Inc.

Biogen Idec Ma Inc.

Kevin Williams

Noubar Boghos Afeyan

Fred E Regnier

Michele Sanicola-Nadel

Susan Gail Schiffer

Paul Rayhorn

Satish Jindal

Fred B Regnier

Steven Donald Miklasz

Sandeep K Paliwal

David Evans

Aruna Pingali

Heather Adkins Huet

The invention provides novel methods for screening a sample to select a ligand to a target of interest and for obtaining information about the ligand and its binding characteristics. Specifically, the claimed multi-dimensional methods involve combining a solution of heterogeneous ligands with the target of interest to screen the ligands on the basis of one or more binding characteristics. Ligands having the first binding characteristic bind to the target of interest thereby to form a target/ligand complex. The complex then optionally is separated from the unbound components using any of a variety of separation techniques, e.g., size exclusion. At least one of the complex or unbound components then is introduced to a second &ldquo;dimension&rdquo;. The second dimension is capable of separating components based upon a second binding characteristic. One then elutes the ligand having the desired binding characteristics.

High speed, automated, continuous flow, multi-dimensional molecular selection and analysis

Growing community of inventors

Natick, MA, United States of America

Kevin Williams