Cargill Inc.

Synthetic Genomics, Inc.

University of Minnesota

Exxonmobil Research and Engineering Company

Bioamber Inc.

Kevin T Watts

Brian Jeffrey Rush

Gregory Michael Poynter

Arlene M Fosmer

Thomas W McMullin

Vernon L McIntosh, Jr

Stephen K Picataggio

Kevin V Martin

Paul Gordon Roessler

Robert Christopher Brown

Beth M Mastel

Jeanette M Huryta

Jessica Roxane Kristof

Gena Roy

Kenneth R Finley

Prachee Prakash

Stuart A Underwood

Keith M Brady

Toby Howard Richardson

Bo Liu

John Verruto

Rekha Seshadri

Claudia Margarete Schmidt-Dannert

Yeast cells having a reductive TCA pathway from pyruvate or phosphoenolpyruvate to succinate, and which include at least one exogenous gene overexpressing an enzyme in that pathway, further contain an exogenous transhydrogenase gene.

Yeast cells having reductive TCA pathway from pyruvate to succinate and overexpressing an exogenous NAD(P+) transhydrogenase enzyme

The present application provides genetically modified yeast cell comprising an active succinate fermentation pathway, as well as methods of using these cells to produce succinate.

Compositions and methods for succinate production

Yeast cells having reductive TCA pathway from pyruvate to succinate and overexpressing an exogenous NAD(P)+ transhydrogenase enzyme

Recombinant yeast cells contain a reductive TCA pathway from phosphoenolpyruvate or pyruvate to succinate. At least one metabolic step in the pathway includes a reaction of NADPH to produce NADP+. The yeast cell contains at least one exogenous NADPH-dependent gene in the pathway from phosphoenolpyruvate or pyruvate to succinate, preferably an NADPH-dependent malate dehydrogensase or fumarate reducase gene (or both).

Yeast cells having NADP(H)-dependent reductive TCA pathway from pyruvate to succinate

This invention describes genes, metabolic pathways, microbial strains and methods to produce methylbutanol and other compounds of interest from renewable feedstocks.

Methylbutanol as an advanced biofuel

Genes and strains of recombinant microorganisms are provided that are engineered to produce fatty alcohols and fatty alcohol derivatives. The organisms can include one, two, three or more transgenes that direct the biosynthesis of one or more fatty alcohols or derivatives. Methods of producing fatty alcohols using transgenic microorganisms are also provided.

Microbial production of fatty alcohols

The described invention provides genetically engineered photosynthetic microorganisms expressing prokaryotic acyl-ACP thioesterases and methods of using the genetically engineered photosynthetic microorganisms for producing free fatty acids and/or fatty acid derivatives.

Photosynthetic microorganisms comprising exogenous prokaryotic acyl-ACP thioesterases and methods for producing fatty acids

This invention describes genes, metabolic pathways, microbial strains and methods to produce 2,6-dimethyloctane as an advanced biofuel from renewable feedstocks.

Dimethyloctane as an advanced biofuel

This invention describes genes, metabolic pathways, microbial strains and methods to produce methyl butanol and other compounds of interest from renewable feedstocks.

The invention provides methods and materials related to producing flavonoids as well as other organic compounds. For example, the invention provides isolated nucleic acids, polypeptides, host cells, and methods and materials for producing flavonoids and other organic compounds.

Microorganisms for the recombinant production of resveratrol and other flavonoids

Growing community of inventors

Minneapolis, MN, United States of America

Kevin T Watts