Southern Illinois University

Northwestern University

The University of Texas System

University of Illinois

Kevin T McVary

Brian Le

Alberto Colombo

Samuel I Stupp

David C Dunand

Dan Harrington

Brian V Le

Carol Podlasek

Provided herein is technology relating to compositions comprising sonic hedgehog protein and therapeutic uses thereof. In particular, the technology relates to compositions comprising a hedgehog protein and one or more peptide amphiphiles for use in methods of treating or preventing stress urinary incontinence and/or erectile dysfunction in a subject.

Methods for treatment of erectile dysfunction with sonic hedgehog compounds

Systems and methods for magnetic induction of a penile prosthesis are disclosed. The magnetic induction system includes a wand that has a coil arrangement covered with a thermal and electrical insulator sheath operable to generate an alternating magnetic field. The coil arrangement of the sheath is configured to receive the length of the penile prosthesis therein. The penile prosthesis may be made from a shape memory material such that application of alternating magnetic fields generated by the magnetic induction system induces eddy currents that raise the temperature of the penile prosthesis to a temperature above the austenitic transformation temperature that allows the penile prosthesis to achieve an erect state.

Systems and methods for magnetic induction of a penile prosthesis

A penile prosthesis is disclosed that can alternate between an erect and flaccid state based on the shape memory properties of an exoskeleton that is responsive to increases and decreases in temperature. The exoskeleton consists of a shape memory alloy, such as nitinol, which in the erect configuration can radially expand and resist axial loads and buckling forces during coitus. The shape memory alloy is temperature-tuned to undergo a change to an erect state under external application of heat and can revert to a flaccid state with cooling below resting penile temperature.

Penile prosthesis

Growing community of inventors

Golf, IL, United States of America

Kevin T McVary