Dsm IP Assets B.v.

Microbia, Inc.

Other

Dsm IP Assests B.v.

Kevin T Madden

Joshua Trueheart

Richard B Bailey

Amir Sherman

Brian Cali

Douglas A Holtzman

Peter Hecht

Maria Mayorga

Mary Maxon

Reed Doten

Dan Dueppen

Joshua Griffin Dunn

Thea Norman

Jeffrey Cruz Silva

Gerald R Fink

John C Royer

G Todd Milne

Todd Milne

Sofie Salama

Eric Summers

Robert Busby

Doug Holtzman

Jeff Silva

Lixin Zhang

The present invention provides systems for producing engineered oleaginous yeast or fungi that express carotenoids.

Production of carotenoids in oleaginous yeast and fungi

The present invention provides systems for producing engineered oleaginous yeast or fungi that express retinolic compounds.

The present invention provides systems for producing engineered oleaginous yeast or fungi that express quinone derived compounds.

Production of quinone derived compounds in oleaginous yeast and fungi

The present invention provides methods for production of one or more sterol compounds. Further provided are methods and systems for producing engineered oleaginous yeast or fungi that are capable of production of one or more sterol compounds, and compositions which utilize the produced sterol compound(s).

Production of sterols in oleaginous yeast and fungi

Methods for improving the production of a secondary metabolite by a fungus by increasing the yield or productivity of the secondary metabolite produced by the fungus are described. The methods include increasing the expression of LYS14, for example, by transforming a cell with a nucleic acid molecule encoding LYS14.

Modulation of secondary metabolite production by zinc binuclear cluster proteins

The invention relates to the production of secondary metabolites by fungi. More particularly, the invention relates to improvement of production of commercially important secondary metabolites by fungi. The invention provides methods for improving secondary metabolite production in a fungus, comprising modulating the expression of a gene involved in regulation of secondary metabolite production.

Methods for improving secondary metabolite production in fungi

The invention relates to regulators of fungal gene expression and their use in commercial and medical applications. More particularly, the invention relates to regulators of fungal genes involved in production of enzymes, secondary metabolites and other useful products, as well as to regulators of genes involved in fungal invasion. The invention provides novel regulators of fungal gene expression, and methods for using regulator genes in commercial and medical applications.

Isolated nucleic acid molecule encoding a regulator of fungal gene expression

Disclosed herein is a chimeric protein comprising a pre-activated transcription factor and a strong transcription activation domain for regulating fungal gene expression, and reagents and methods for constructing and using said protein.

Chimeric pre-activated transcription factors

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Arlington, MA, United States of America

Kevin T Madden