Advanced Inhalation Research, Inc.

Gilead Sciences, Inc.

Civitas Therapeutics, Inc.

Pari Gmbh Spezialisten Fur Effektive Inhalation

Alkermes, Inc.

Pari Gmbh Spezialisten Fur Effetive Inhalation

Kevin Stapleton

Ernest E Penachio

Alan Bruce Montgomery

Lloyd Johnston

Thomas Hofmann

Mark Wolff

David A Edwards

Thomas Gallem

Martin Knoch

Jake P Ganem

Brian Noble

Chuck Ganem

Colleen Ellwanger

William Baker

Mark DeLong

Craig Dunbar

Mark Delong

David Lee Foshee

Andrew Jones

Robert Waldner

Colleen Conlon

Jason R Durkin

Tim Coker

Andrew Ziegler

Timothy B Coker

Sarah Dreesen

Robert W Spaller

Margaret Millar Saunders

Ryan Mcmanus

An improved inhalation device is provided for facilitating inhalation by a patient of powder medicaments contained in a receptacle. The inhalation device includes a staple assembly comprising a plunger and staple that are securely and robustly coupled to one another. Embodiments of the inhalation device have a cap that prevents or reduces the amount of dust and grime entering into the device. The cap is additionally configured to prevent or reduce inadvertent and unintentional operation of the device. The body portion and first casing portion of certain embodiments of the inhalation device are sealably coupled, restricting or reducing undesirable flow pathways that have an adverse effect on the operation of the device.

Powder inhaler devices

A method for improvement of tolerance for therapeutically effective agents delivered by inhalation comprising a pretreatment of a patient with a nebulized lidocaine or a lidocaine-like compound administered immediately or up to about thirty minutes before administration of the primary therapeutically effective agent. The pretreatment of the patient with the nebulized lidocaine or a lidocaine-like compound improves airway tolerance and deposition of the agent in the lungs and makes such deposition more safe, efficacious, controllable and predictable. The method of the invention is especially useful for enhancement of deposition of immunosuppressive agents in the lung(s) of transplant patients, improved tolerance of the drugs by reducing cough, and improving pulmonary drug deposition.

Method for improvement of tolerance for therapeutically effective agents delivered by inhalation

An anti-tussive nebulized solution for targeted delivery of lidocaine into conducting and central airways. A method for treatment of cough and tussive attacks or episodes using said lidocaine solution. A nebulized lidocaine solution administered in daily dose from about 10 mg to 80 mg of lidocaine dissolved in a saline and nebulized into an aerosol having a mass median aerodynamic diameter 3 &#x3bc;m to 10 &#x3bc;m and a geometric standard deviation less than 1.7 using an electronic nebulizer.

Targeted delivery of lidocaine and other local anesthetics and a method for treatment of cough, asthma and tussive attacks

Targeted delivery of lidocaine and other local anesthetics and a method for treatment of cough and tussive attacks

Inhalation device and associated method for facilitating inhalation by a patient of powder medicaments contained in a receptacle. The inhalation device has a chamber for receiving the receptacle. A ring is circumferentially coupled to an inner surface of the chamber to achieve a higher reproducible emitted dose of medicament from the receptacle. The inhalation device also includes an improved implement for puncturing the receptacle, requiring less force and experiencing fewer failures. The inhalation device also includes a means for indicating readiness.

Inhalation device and method

Inhalation device and associated method for facilitating inhalation by a patient of powder medicaments contained in a receptacle. The inhalation device has a chamber for receiving the receptacle. A ring is circumferentially coupled to an inner surface of the chamber to achieve a higher reproducible emitted dose of medicament from the receptacle. The inhalation device also includes an improved implement for puncturing the receptacle, requiring less force and experiencing fewer failures.

Inhaler and associated method for facilitating inhalation of dry powder medicaments by a patient. The inhaler is light and compact, allowing for convenient storage and portability by a patient. Additionally, a minimal number of steps are required by the patient to use the device from start to finish. The inhaler is self-contained, being provided to the patient with medicament having been pre-stored in a powder chamber. Upon release from this chamber, an accurate dosage of the dry powder medicament is available for inhalation. The inhaler may simply be disposed of following use.

Method and apparatus for providing a precisely controlled amount of dry material to a container. In one embodiment, a system is provided for automated container filling. The system includes a container handling mechanism that includes a container block defining a container receptacle, and a cap carrier defining a cap receptacle. The system also includes a dosing portion having a dosing plate defining a dosing hole. The dosing plate is movable between two positions so that when the dosing plate is in the first position the dosing hole is positioned to receive a dose of powder. When the dosing plate is in the second position, the dosing hole is positioned to dispense the dose of powder into the container receptacle.

System for filling containers

Inhalation device

Metering aerosol dispensing device comprising an aerosol container ( ); a nozzle ( ) that is arranged in a nozzle body ( ), whereby the aerosol is dispensed via said nozzle when the aerosol container ( ) is pushed against the body ( ) of the nozzle once the metering aerosol dispensing device is actuated; a meter ( ) that counts the number of times that the metering aerosol dispensing device is actuated; and an actuating device ( ) that enables the meter ( ) to move forward when the metering aerosol dispensing device is actuated. The invention is characterized in that the actuating device ( ) is designed and arranged in the metering aerosol dispensing device in such a way that the body ( ) of the nozzle is accomodated in the interior of the actuating device ( ) and the nozzle ( ) is released in order to produce aerosol in an unrestricted manner.

Actuating device for meters and metering aerosol dispensing device with an actuating device for meters

The invention describes a mouthpiece for an inhalation therapy unit wherein an aerosol for inhalation is prepared for a patient, said mouthpiece comprising a substantially tubular base ( ), in the wall of which an orifice ( ) is formed, and a flat, elastic valve member ( ), which is adapted in dimension and shape to the orifice ( ) for the closing thereof and which is secured to the mouthpiece in such a manner that during an inspiration process through the mouthpiece the orifice ( ) is closed and during an expiration process directed into the mouthpiece the orifice ( ) is opened. According to the invention, at least one enlarged contact surface ( ) is provided at the orifice ( ) for the accumulation and holding of an amount of liquid by adhesion. This contact surface is established both by an outwardly directed collar ( ) surrounding the orifice and by a narrow bar ( ) which extends into the orifice ( ) for example transversely through the center of the orifice in longitudinal direction of the mouthpiece or transversely across the mouthpiece.

Mouth piece for inhalation therapy units

Growing community of inventors

Seattle, WA, United States of America

Kevin Stapleton