Massachusetts Institute of Technology

Sanofi

Pharyx, Inc.

Kevin Shao-Kwan Lee

Rajeev J Ram

Harry Lee

Horst Blum

Michelangelo Canzoneri

Shireen Goh

Rajeev Jagga Ram

Control of humidity in chemical reactors, and associated systems and methods, are generally described. In certain embodiments, the humidity within gas transport conduits and chambers can be controlled to inhibit unwanted condensation within gas transport pathways. By inhibiting condensation within gas transport pathways, clogging of such pathways can be limited (or eliminated) such that transport of gas can be more easily and controllably achieved. In addition, strategies for purging condensed liquid from chemical reactor systems are also described.

Humidity control in chemical reactors

A microreactor with a reaction chamber comprising two sub-chambers with reconfigurable volumes, an input conduit with input valve, an un-filtered output conduit with first output valve, and a filtered output conduit with a second output valve is used to perform a method to control a different dilution rate for cells and molecules in continuous culture bioprocesses. In preferred embodiments flow control is achieved using the difference in volume of the two sub-chambers.

Methods and apparatus for independent control of product and reactant concentrations

The present invention provides apparatus and methods to operate microreactor devices through the controlled delivery of pressurized fluids. A heated reservoir, a heated manifold, and a heater for the microreactor device provides for the delivery of a pressurized gas while minimizing evaporation and condensation; and a fluid interface and pressure interlock provides for the delivery of aseptic fluids while minimizing contamination and fluid loss.

Apparatus and methods to operate a microreactor

The present invention provides apparatus and methods for measuring the optical density of a fluid by measuring the light transmission through a reconfigurable optical path. The optical path is reconfigured by the deflection of an elastic membrane wherein the optical path length through the fluid is determined by the position of the membrane relative to a fixed surface. The optical density can be determined from two measurements with different optical path lengths through the fluid.

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Cambridge, MA, United States of America

Kevin Shao-Kwan Lee