Glaxo Group Limited

Kevin S Cardwell

Michael D Dowle

David Middlemiss

Barry C Ross

David I Scopes

Torquil I Jack

Duncan B Judd

Stephen Paul Watson

Charles Edward Wade

John G Montana

Claire Frances Crawford

Suzanne Helen Davies

Colin David Eldred

Pritom Shah

Martin Pass

This invention relates to methods of making a compound of formula (I) and intermediates for same the compounds of formula (I) being useful for treating cardiovascular and inflammatory diseases such as atherosclerosis.

Processes

Processes for preparing pyrimidine compounds

The invention provides compounds of formula (I): ##STR1## or a physiologically acceptable salt, solvate or metabolically labile ester thereof wherein the R groups are defined in the specification. The compounds may be used in the treatment or prophylaxis of hypertension and diseases associated with cognitive disorders.

Benzofuran derivatives

The invention provides compounds of the general formula (I) ##STR1## and physiologically acceptable salts, solvates or non-toxic metabolically labile esters thereof where R.sup.1 represents a halogen atom; Ar represents the group ##STR2## R.sup.3 represents a C-linked tetrazolyl group; R.sup.4 and R.sup.5, which may be the same or different, each independently represent a hydrogen atom or a halogen atom or a C.sub.1-6 alkyl group; and

The invention provides compounds of formula (I): ##STR1## or a physiologically acceptable salt, solvate or metabolically labile ester thereof wherein

The invention provides compounds of formula (I): ##STR1## or a physiologically acceptable salt, solvate or metabolically labile ester thereof. The compounds may be used in the treatment or prophylaxis of hypertension and diseases associated with cognitive disorders.

Pyrazole containing benzofuran derivatives and pharmaceutical

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Ware, United Kingdom

Kevin S Cardwell