Novartis Ag

Nektar Therapeutics

Kevin Russert Walsh

Carlos A Schuler

William W Alston

Andrew Clark

Adrian Edward Smith

Derrick J Parks

Scot Cheu

Normand Nantel

Jamshed Ghandhi

An aerosolization apparatus comprises a container containing a pharmaceutical formulation, the pharmaceutical formulation comprising an active agent and a propellant. The aerosolization apparatus further comprises a metering chamber in communication with the container, the metering chamber adapted to hold a metered amount of the pharmaceutical formulation, a valve to allow the metered amount of the pharmaceutical formulation to be released from the metering chamber when the valve is actuated, and a pressurizer that applies pressure to the pharmaceutical formulation in the metering chamber while the pharmaceutical formulation is being released from the metering chamber. In one version, the metering chamber is sized so that at least 2 mg, and preferably at least 5 mg, of the active agent is be aerosolized for delivery to a user during inhalation.

Increased dosage metered dose inhaler

The invention provides systems and methods for measuring the mass of a substance. In one method, energy is applied to a substance and a response resulting from the application of energy as measured. The mass of the substance is then determined based at least in part on the measured response.

Systems and methods for non-destructive mass sensing

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San Francisco, CA, United States of America

Kevin Russert Walsh