Arizona State University

Motorola Corporation

Columbia University

Kevin Reinhart

Stuart Lindsay

Peiming Zhang

Jin He

Colin P Nuckolls

Jinyao Tang

Alan L James

A device for reading the sequence of a polymer, consisting of a first electrode and a second electrode, each electrode being functionalized with a reader molecule strongly bonded to the electrodes, but forming weak bonds with a molecule to be sequenced. In particular, the reader molecule is designed to form bonds with at least two points on the target molecule such that the target molecule is trapped between a first reader molecule on one electrode and a second reader molecule on the second electrode, with the overall size of the molecular complex being small enough to permit significant electric current to flow.

Trans-base tunnel reader for sequencing

The present invention provides a device for analyzing the composition of a heteropolymer comprising a carbon nanotube through which the heteropolymer is driven by electrophoresis. The carbon nanotube also serves as one electrode in a reading circuit. One end of the carbon nanotube is held in close proximity to a second electrode, and each end of the carbon nanotube is functionalized with flexibly-tethered chemical-recognition moieties, such that one will bind one site on the emerging polymer, and the second will bind another site in close proximity, generating an electrical signal between the two electrodes when the circuit is completed by the process of chemical recognition.

Nanopore and carbon nanotube based DNA sequencer

The present invention is directed to systems, devices and methods for identifying biopolymers, such as strands of DNA, as they pass through a constriction such as a carbon nanotube nanopore. More particularly, the invention is directed to such systems, devices and methods in which a newly translocated portion of the biopolymer forms a temporary electrical circuit between the nanotube nanopore and a second electrode, which may also be a nanotube. Further, the invention is directed to such systems, devices and methods in which the constriction is provided with a functionalized unit which, together with a newly translocated portion of the biopolymer, forms a temporary electrical circuit that can be used to characterize that portion of the biopolymer.

Nanopore and carbon nanotube based DNA sequencer and a serial recognition sequencer

A method of fabricating a high vacuum device by providing two major, parallel spaced apart glass sides in a substantial vacuum, forming a continuous edge between the sides and forming a tack with a metallic diffusion bond between the sides. The metallic diffusion bond is formed of materials that bond and cure faster than the material of the continuous edge so that the tack holds the sides in a fixed position while the continuous edge is curing.

Growing community of inventors

Chandler, AZ, United States of America

Kevin Reinhart